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    Zfp148 zinc finger protein 148 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58820, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp148provided by RGD
    Official Full Name
    zinc finger protein 148provided by RGD
    Primary source
    RGD:62063
    See related
    EnsemblRapid:ENSRNOG00000001789 AllianceGenome:RGD:62063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zbp-89; Znf148
    Summary
    Enables transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and protein-containing complex assembly. Predicted to be located in Golgi apparatus and nucleoplasm. Orthologous to human ZNF148 (zinc finger protein 148). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 171.9), Thymus (RPKM 162.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp148 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (80780865..80890877, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67276455..67385803, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70509909..70618422, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene solute carrier family 12, member 8 Neighboring gene uncharacterized LOC134481081 Neighboring gene uncharacterized LOC134481082 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene WAS/WASL-interacting protein family member 1-like Neighboring gene uncharacterized LOC120095666 Neighboring gene sorting nexin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription factor ZBP-89 is required for STAT1 constitutive expression. Bai L, et al. Nucleic Acids Res, 2003 Dec 15. PMID 14654702, Free PMC Article
    2. ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter. Merchant JL, et al. Mol Cell Biol, 1996 Dec. PMID 8943318, Free PMC Article
    3. ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate. Bai L, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17560543, Free PMC Article
    4. Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Takeuchi A, et al. Nat Genet, 2003 Feb. PMID 12524542
    5. Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. Hasegawa T, et al. J Biol Chem, 1997 Feb 21. PMID 9030551

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZBP-89 binds directly to the STAT1 promoter G-rich element
      Title: Transcription factor ZBP-89 is required for STAT1 constitutive expression.
    2. ataxia telangiectasia mutated protein phosphorylation of ZBP-89 contributes to Histone deacetylase inhibitors induction of p21(waf1) gene expression
      Title: ATM phosphorylates ZBP-89 at Ser202 to potentiate p21waf1 induction by butyrate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamete generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 148
    Names
    transcription factor ZBP-89
    zinc finger DNA-binding protein 89

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031615.2 → NP_113803.1  zinc finger protein 148

      See identical proteins and their annotated locations for NP_113803.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q62806
      UniProtKB/TrEMBL
      A6IRL4
      Related
      ENSRNOP00000002435.4, ENSRNOT00000002435.6
      Conserved Domains (3) summary
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171 → 193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214 → 238
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      80780865..80890877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088601.2 → XP_038944529.1  zinc finger protein 148 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R3F5
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039088604.2 → XP_038944532.1  zinc finger protein 148 isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q044
      Related
      ENSRNOP00000111549.1, ENSRNOT00000156651.1
      Conserved Domains (3) summary
      sd00017
      Location:131 → 151
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:129 → 151
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:172 → 196
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006248435.5 → XP_006248497.1  zinc finger protein 148 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R3F5
      Related
      ENSRNOP00000071067.2, ENSRNOT00000086955.3
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039088602.2 → XP_038944530.1  zinc finger protein 148 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R3F5
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    5. XM_063270737.1 → XP_063126807.1  zinc finger protein 148 isoform X2

      UniProtKB/Swiss-Prot
      Q62806
      UniProtKB/TrEMBL
      A6IRL4

    6. XM_063270738.1 → XP_063126808.1  zinc finger protein 148 isoform X2

      UniProtKB/Swiss-Prot
      Q62806
      UniProtKB/TrEMBL
      A6IRL4

    7. XM_039088603.2 → XP_038944531.1  zinc finger protein 148 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R3F5
      Conserved Domains (3) summary
      sd00017
      Location:179 → 199
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:177 → 199
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:220 → 244
      zf-H2C2_2; Zinc-finger double domain

    8. XM_063270736.1 → XP_063126806.1  zinc finger protein 148 isoform X2

      UniProtKB/Swiss-Prot
      Q62806
      UniProtKB/TrEMBL
      A6IRL4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62806.1 GenPept UniProtKB/Swiss-Prot:Q62806

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