Cdc25b cell division cycle 25B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdc25bprovided by RGD
Official Full Name: cell division cycle 25Bprovided by RGD
Primary source: RGD:621500
See related: EnsemblRapid:ENSRNOG00000021248 AllianceGenome:RGD:621500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; positive regulation of cell cycle process; and protein phosphorylation. Predicted to act upstream of or within female meiosis I; oocyte maturation; and positive regulation of protein kinase activity. Predicted to be located in centrosome and spindle pole. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 404.3), Lung (RPKM 87.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138860148..138870287)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (118407127..118417272)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123731539..123741696)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133919 (e-PCR)
- UniSTS:217202

Cdc25b (e-PCR), detects polymorphism
- UniSTS:276140

RH131478 (e-PCR)
- UniSTS:214761

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in female meiosis I	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female meiosis I	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: M-phase inducer phosphatase 2

Names: dual specificity phosphatase Cdc25B

NP_001376142.1

EC 3.1.3.48

NP_598256.2

EC 3.1.3.48

XP_038960121.1

EC 3.1.3.48

XP_038960123.1

EC 3.1.3.48

XP_063139110.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389213.1 → NP_001376142.1 M-phase inducer phosphatase 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A7K8, A0A8I6GIX5

Related

ENSRNOP00000091343.2, ENSRNOT00000119042.2

Conserved Domains (2) summary

cd01530
Location:381 → 500

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:111 → 352

M-inducer_phosp; M-phase inducer phosphatase
NM_001429734.1 → NP_001416663.1 M-phase inducer phosphatase 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001429735.1 → NP_001416664.1 M-phase inducer phosphatase 2 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_133572.2 → NP_598256.2 M-phase inducer phosphatase 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

P48966

UniProtKB/TrEMBL

A6HQC8, F1LQS5

Related

ENSRNOP00000106275.1, ENSRNOT00000122290.1

Conserved Domains (2) summary

cd01530
Location:407 → 526

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:111 → 378

M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

138860148..138870287

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283040.1 → XP_063139110.1 M-phase inducer phosphatase 2 isoform X2

Related

ENSRNOP00000088213.2, ENSRNOT00000101513.2
XM_039104193.2 → XP_038960121.1 M-phase inducer phosphatase 2 isoform X1

Related

ENSRNOP00000096779.1, ENSRNOT00000103719.2

Conserved Domains (2) summary

cd01530
Location:393 → 512

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:111 → 364

M-inducer_phosp; M-phase inducer phosphatase
XM_039104195.2 → XP_038960123.1 M-phase inducer phosphatase 2 isoform X3

Conserved Domains (2) summary

cd01530
Location:209 → 328

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...

pfam06617
Location:1 → 180

M-inducer_phosp; M-phase inducer phosphatase