Cth cystathionine gamma-lyase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cthprovided by RGD
Full Name: cystathionine gamma-lyaseprovided by RGD
Primary source: RGD:2443
See related: EnsemblRapid:ENSRNOG00000010658 AllianceGenome:RGD:2443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CGL; CSE
Summary: Predicted to enable carbon-sulfur lyase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in glutathione metabolic process; negative regulation of cell growth; and negative regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Used to study cataract. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 4136.0) and Kidney (RPKM 990.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q45

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (249634731..249661066, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (246975888..247002234, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (264266959..264293040, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine gamma-lyase expression in a rat model of intracerebral hemorrhage.
Title: Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage.
DR1-CSE/H2S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
Title: DR1-CSE/H(2)S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
CD4(+) T-Cell Endogenous Cystathionine gamma Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.
Title: CD4(+) T-Cell Endogenous Cystathionine γ Lyase-Hydrogen Sulfide Attenuates Hypertension by Sulfhydrating Liver Kinase B1 to Promote T Regulatory Cell Differentiation and Proliferation.
Activity of Gas Transmitters in Vessels of the Anterior Abdominal Wall after Implantation of a Polypropylene Mesh.
Title: Activity of Gas Transmitters in Vessels of the Anterior Abdominal Wall after Implantation of a Polypropylene Mesh.
indings show that brief and repeated ischemic postconditioning increased the expression of CSE after ischemia/reperfusion in diabetes mellitus
Title: Cystathionine γ-Lyase Is Involved in the Renoprotective Effect of Brief and Repeated Ischemic Postconditioning After Renal Ischemia/Reperfusion Injury in Diabetes Mellitus.
Delayed gastric emptying in diabetic rats is due to down-regulation of the hydrogen sulfide biosynthesis enzyme, cystathionine gamma lyase.
Title: Delayed gastric emptying in diabetic rats caused by decreased expression of cystathionine gamma lyase and H(2) S synthesis: in vitro and in vivo studies.
3, 5, 7, 3', 4'-pentamethoxyflavone treatment of middle aged rats appeared to increase production of NO and H2S from the blood vessels by upregulating the expression of eNOS and cystathione-gamma-lyase..
Title: Increased vascular eNOS and cystathionine-γ-lyase protein after 6 weeks oral administration of 3, 5, 7, 3', 4'-pentamethoxyflavone to middle-aged male rats.
The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response
Title: The Paracrine Effect of Skeletal Myoblasts Is Cardioprotective Against Oxidative Stress and Involves EGFR-ErbB4 Signaling, Cystathionase, and the Unfolded Protein Response.
These findings indicated that nitric oxide mediated the stimulatory effect of gastric acid on hydrogen sulfide release and protein expression of cystathione gamma lyase.
Title: Gastric acid induces mucosal H2S release in rats by upregulating mRNA and protein expression of cystathionine gamma lyase.
Up Regulation of cystathione gamma lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol-Caffeine Induced Left Ventricular Hypertrophy
Title: Up Regulation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol-Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-cysteine desulfhydrase activity	IEA Inferred from Electronic Annotation more info
enables L-cystine L-cysteine-lyase (deaminating)	IEA Inferred from Electronic Annotation more info
enables L-cystine L-cysteine-lyase (deaminating)	ISO Inferred from Sequence Orthology more info
enables L-cystine L-cysteine-lyase (deaminating)	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cystathionine gamma-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cystathionine gamma-lyase activity	IEA Inferred from Electronic Annotation more info
enables cystathionine gamma-lyase activity	ISO Inferred from Sequence Orthology more info
enables cystathionine gamma-lyase activity	ISS Inferred from Sequence or Structural Similarity more info
enables homocysteine desulfhydrase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	TAS Traceable Author Statement more info	PubMed
enables selenocystathionine gamma-lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cysteine biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cysteine biosynthetic process via cystathionine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cysteine biosynthetic process via cystathionine	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process via cystathionine	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen sulfide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen sulfide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen sulfide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of aortic smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aortic smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein sulfhydration	ISO Inferred from Sequence Orthology more info
involved_in protein sulfhydration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	ISO Inferred from Sequence Orthology more info
involved_in protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	ISS Inferred from Sequence or Structural Similarity more info
involved_in transsulfuration	IBA Inferred from Biological aspect of Ancestor more info
involved_in transsulfuration	IEA Inferred from Electronic Annotation more info
involved_in transsulfuration	ISO Inferred from Sequence Orthology more info
involved_in transsulfuration	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cystathionine gamma-lyase

Names: CTL target antigen; PRB-RA; cystathionase (cystathionine gamma-lyase); cysteine desulfhydrase; cysteine-protein sulfhydrase; gamma-cystathionase; homocysteine desulfhydrase; probasin-related antigen

NP_058770.2

EC 4.4.1.1

EC 4.4.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017074.2 → NP_058770.2 cystathionine gamma-lyase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P18757

UniProtKB/TrEMBL

A6HWT2, Q9EQS4

Related

ENSRNOP00000058914.1, ENSRNOT00000067843.4

Conserved Domains (1) summary

pfam01053
Location:18 → 394

Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme