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    Aprt adenine phosphoribosyl transferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292072, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Aprtprovided by RGD
    Official Full Name
    adenine phosphoribosyl transferaseprovided by RGD
    Primary source
    RGD:1307758
    See related
    AllianceGenome:RGD:1307758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables AMP binding activity. Involved in cellular response to insulin stimulus and lactation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 571.1), Lung (RPKM 480.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aprt in Genome Data Viewer
    Location:
    19q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67534737..67537027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50626201..50628491, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55387288..55389256, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103694354 Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene trafficking protein particle complex subunit 2L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification of adenine phosphoribosyltransferase by affinity chromatography. Hershey HV, et al. Prep Biochem, 1978. PMID 748918
    2. The rat adenine phosphoribosyltransferase sequence shows evolutionary rate variation among exons in rodents. Fieldhouse D, et al. Genome, 1993 Dec. PMID 8112572
    3. Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes. Beardsley S, et al. Biochem J, 1988 Mar 1. PMID 2451510, Free PMC Article
    4. Identification of two novel mutations in adenine phosphoribosyltransferase gene in patients with 2,8-dihydroxyadenine urolithiasis. Taniguchi A, et al. Nucleosides Nucleotides Nucleic Acids, 2004 Oct. PMID 15571218
    5. Three-dimensional structure of human adenine phosphoribosyltransferase and its relation to DHA-urolithiasis. Silva M, et al. Biochemistry, 2004 Jun 22. PMID 15196008

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenine phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within AMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adenine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in grooming behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT acts_upstream_of_or_within grooming behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within grooming behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within purine ribonucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenine phosphoribosyltransferase
    NP_001013079.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013061.2 → NP_001013079.1  adenine phosphoribosyltransferase

      See identical proteins and their annotated locations for NP_001013079.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P36972
      UniProtKB/TrEMBL
      A0A8L2QU71, A6IZS8
      Conserved Domains (1) summary
      PRK02304
      Location:6 → 180
      PRK02304; adenine phosphoribosyltransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67534737..67537027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36972.1 GenPept UniProtKB/Swiss-Prot:P36972

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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