Csnk2b casein kinase 2 beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Csnk2bprovided by RGD
Official Full Name: casein kinase 2 betaprovided by RGD
Primary source: RGD:619978
See related: EnsemblRapid:ENSRNOG00000000847 AllianceGenome:RGD:619978
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ck2
Summary: Enables ribonucleoprotein complex binding activity. Involved in liver regeneration and response to testosterone. Located in cell projection; chromatin; and nuclear matrix. Biomarker of myocardial infarction. Orthologous to human CSNK2B (casein kinase 2 beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 741.5), Heart (RPKM 387.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3704833..3709999)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3700363..3705331)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5108692..5113675, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
Title: Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
Title: CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca(2+)-Triggered Release in Neuroendocrine Cells.
Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic beta-Cells of the Line INS-1.
Title: Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1.
NADPH oxidase activity is decreased by 5d, a novel analogue of 3-n-butylphthalide, through the positive regulation of CK2 after ischemia/reperfusion injury
Title: 5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury.
alphaB-crystallin protects rat articular chondrocytes against CK2 inhibition-induced apoptosis.
Title: Alpha B-Crystallin Protects Rat Articular Chondrocytes against Casein Kinase II Inhibition-Induced Apoptosis.
ANXA1 promotes microglial activation and migration during oxygen-glucose deprivation/reperfusion via FPR, and CK2 target alpha-E-catenin phosphorylation is involved in this process.
Title: Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion.
Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
Title: Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2.
CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.
our data show that CK2 induces the expression of the antiapoptotic gene Mcl-1 through activation of the SRF-mediated pathway in hippocampal CA1 neurons
Title: Protein kinase CK2 enhances Mcl-1 gene expression through the serum response factor-mediated pathway in the rat hippocampus.
Peroxynitrite activates Nrf2 via CK2 signaling, leading to the upregulation of HO-1 in primary chondrocytes.
Title: Protein kinase CK2 mediates peroxynitrite-induced heme oxygenase-1 expression in articular chondrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137048 (e-PCR)
- UniSTS:219137

RH129972 (e-PCR)
- UniSTS:213260

D20Yum50 (e-PCR)
- UniSTS:526121

MARC_3347-3348:966881404:1 (e-PCR)
- UniSTS:231017

MARC_3347-3348:991937077:1 (e-PCR)
- UniSTS:231017

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adiponectin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in endothelial tube morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral life cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in symbiont-mediated disruption of host cell PML body	IEA Inferred from Electronic Annotation more info
involved_in symbiont-mediated disruption of host cell PML body	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in PML body	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IEA Inferred from Electronic Annotation more info
part_of protein kinase CK2 complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: casein kinase II subunit beta

Names: CK II beta; Csnk2b-Ly6g5b; casein kinase 2, beta polypeptide; casein kinase 2, beta subunit; casein kinase II beta subunit; phosvitin

NP_001030315.1

EC 2.7.11.1

NP_112283.1

EC 2.7.11.1

XP_006256143.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035238.2 → NP_001030315.1 casein kinase II subunit beta

See identical proteins and their annotated locations for NP_001030315.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC078807, BX883045

UniProtKB/Swiss-Prot

P67874

UniProtKB/TrEMBL

N0E459, Q68G11

Related

ENSRNOP00000098131.1, ENSRNOT00000120467.2

Conserved Domains (1) summary

smart01085
Location:8 → 191

CK_II_beta; Casein kinase II regulatory subunit
NM_031021.3 → NP_112283.1 casein kinase II subunit beta

See identical proteins and their annotated locations for NP_112283.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BX883045, EV778558

UniProtKB/Swiss-Prot

P67874

UniProtKB/TrEMBL

N0E459, Q68G11

Conserved Domains (1) summary

smart01085
Location:8 → 191

CK_II_beta; Casein kinase II regulatory subunit