Trhr thyrotropin releasing hormone receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trhrprovided by RGD
Official Full Name: thyrotropin releasing hormone receptorprovided by RGD
Primary source: RGD:3904
See related: EnsemblRapid:ENSRNOG00000005048 AllianceGenome:RGD:3904
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity and thyrotropin-releasing hormone receptor activity. Involved in positive regulation of cytosolic calcium ion concentration and positive regulation of protein-containing complex assembly. Located in cell surface. Used to study hypertension. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 16.6), Thymus (RPKM 13.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (77233175..77277988)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (75348672..75393310)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (83113641..83153520)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-localization of LepRb and TRHR1 is not observed on individual fibers in the hindbrain, but these two fiber types co-mingle in vagal and reticular nuclei.
Title: Co-localization of TRHR1 and LepRb receptors on neurons in the hindbrain of the rat.
The expression and localization of TRH-R1 and TRH-R2 in postnatal development and ethane dimethane sulfonate treated rat testes were observed.
Title: Expression of thyrotropin-releasing hormone receptors in rat testis and their role in isolated Leydig cells.
These data suggest that the proposed disulfide bond of proTRH is involved in sorting of proTRH-derived peptides and in their retention within maturing secretory granules.
Title: Disruption of disulfide bond formation alters the trafficking of prothyrotropin releasing hormone (proTRH)-derived peptides.
Our results demonstrate that whereas the TRH receptor uses a G(q/11) protein for transducing the Ca2+ signal during the initial response to TRH, this G-protein is not involved in the TRH-induced inhibition of endogenous r-ERG currents in pituitary cells.
Title: Specificity of TRH receptor coupling to G-proteins for regulation of ERG K+ channels in GH3 rat anterior pituitary cells.
the mechanisms of suckling-induced lactation involve region-specific regulation of TRHR1 and proTRH mRNAs in the central nervous system notably at the hypothalamic level.
Title: Thyrotrophin-releasing hormone receptor 1 and prothyrotrophin-releasing hormone mRNA expression in the central nervous system are regulated by suckling in lactating rats.
Dimerization and phosphorylation are modulated by agonist stimulation
Title: Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.
Data provide new evidence for a novel intrathyroidal regulatory pathway of thyroid hormone secretion via paracrine/autocrine TRH signaling.
Title: Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables thyrotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables thyrotropin-releasing hormone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyrotropin-releasing hormone receptor

Names: TRH-R; thyroliberin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.