Cyth3 cytohesin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyth3provided by RGD
Official Full Name: cytohesin 3provided by RGD
Primary source: RGD:620399
See related: EnsemblRapid:ENSRNOG00000001065 AllianceGenome:RGD:620399
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sec7; Pscd3; Sec7C
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in Golgi vesicle transport. Predicted to act upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Predicted to be located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Orthologous to human CYTH3 (cytohesin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 457.5), Lung (RPKM 456.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15953781..16076584, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10840137..10933792, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12877559..12907771, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi vesicle transport	IEA Inferred from Electronic Annotation more info
involved_in Golgi vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of epithelial cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytohesin-3

Names: PH, SEC7 and coiled-coil domain-containing protein 3; SEC7 homolog C; pleckstrin homology, Sec7 and coiled/coil domains 3; rSec7-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053912.2 → NP_446364.2 cytohesin-3

See identical proteins and their annotated locations for NP_446364.2

Status: PROVISIONAL

Source sequence(s)

BC101884

UniProtKB/Swiss-Prot

P97696

UniProtKB/TrEMBL

Q3T1J6

Related

ENSRNOP00000001412.9, ENSRNOT00000001412.9

Conserved Domains (2) summary

cd01252
Location:263 → 382

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:66 → 248

Sec7; Sec7 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

15953781..16076584 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271013.1 → XP_063127083.1 cytohesin-3 isoform X3

UniProtKB/TrEMBL

A6K1K3
XM_063271012.1 → XP_063127082.1 cytohesin-3 isoform X2

Related

ENSRNOP00000109621.1, ENSRNOT00000129902.1
XM_039089028.2 → XP_038944956.1 cytohesin-3 isoform X3

UniProtKB/Swiss-Prot

P97696

UniProtKB/TrEMBL

A6K1K3

Related

ENSRNOP00000112358.1, ENSRNOT00000132895.1

Conserved Domains (2) summary

cd01252
Location:215 → 334

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:18 → 200

Sec7; Sec7 domain
XM_039089024.2 → XP_038944952.1 cytohesin-3 isoform X1

UniProtKB/Swiss-Prot

P97696

Related

ENSRNOP00000103429.1, ENSRNOT00000128862.1

Conserved Domains (2) summary

cd01252
Location:335 → 454

PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain

pfam01369
Location:138 → 320

Sec7; Sec7 domain