Gsta4 glutathione S-transferase alpha 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gsta4provided by RGD
Official Full Name: glutathione S-transferase alpha 4provided by RGD
Primary source: RGD:1309970
See related: EnsemblRapid:ENSRNOG00000030449 AllianceGenome:RGD:1309970
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables organic cyclic compound binding activity and toxic substance binding activity. Involved in several processes, including cellular response to lithium ion; response to herbicide; and response to zinc ion. Predicted to be located in cytosol. Orthologous to human GSTA4 (glutathione S-transferase alpha 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 1098.2), Liver (RPKM 846.5) and 7 other tissues See more
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Genomic context

Location:: 8q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (87947247..87964490)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (79066967..79084193)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (85497557..85514732)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
Title: Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis.
The results demonstrate that CYP2E1 induces iNOS-independent free radical generation and subsequently modulates the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb- and paraquat-treated PMNs.
Title: CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes.
These results showed and mapped naturally occurring genetic differences in the expression of Gsta4 associated both with a highly significant increase in the survival of axotomized motoneurons and with a trans-regulation of several molecular pathways.
Title: Naturally occurring genetic variability in expression of Gsta4 is associated with differential survival of axotomized rat motoneurons.
A novel haplotype variant in the rat Gsta4 gene leads to increased brain transcript levels in ethanol-preferring AA rats compared to nonpreferring ANA rats, and may contribute to the difference in lifespan between these rodent lines.
Title: Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lithium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to herbicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase alpha-4

Names: GST 8-8; GST A4-4; GST K; GST Yk; glutathione S-transferase A4; glutathione S-transferase Yk; glutathione transferase

NP_001100310.1

EC 2.5.1.18

XP_063121254.1

EC 2.5.1.18

XP_063121255.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106840.1 → NP_001100310.1 glutathione S-transferase alpha-4

See identical proteins and their annotated locations for NP_001100310.1

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/Swiss-Prot

P14942

UniProtKB/TrEMBL

A6HBU1, A9UMW1, B6DYP9

Related

ENSRNOP00000075572.1, ENSRNOT00000090146.3

Conserved Domains (2) summary

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cl00388
Location:4 → 82

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

87947247..87964490

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265184.1 → XP_063121254.1 glutathione S-transferase alpha-4 isoform X1

UniProtKB/Swiss-Prot

P14942

UniProtKB/TrEMBL

A9UMW1, B6DYP9
XM_063265185.1 → XP_063121255.1 glutathione S-transferase alpha-4 isoform X2