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    Serpinb2 serpin family B member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60325, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Serpinb2provided by RGD
    Official Full Name
    serpin family B member 2provided by RGD
    Primary source
    RGD:621823
    See related
    EnsemblRapid:ENSRNOG00000002460 AllianceGenome:RGD:621823
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pai2a
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in cytoplasm. Predicted to be active in cornified envelope and extracellular space. Orthologous to human SERPINB2 (serpin family B member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 13.4), Spleen (RPKM 10.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Serpinb2 in Genome Data Viewer
    Location:
    13p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (24051933..24065032)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (23537312..23551823)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (27449907..27463015)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled 1 pseudogene 3 Neighboring gene serpin family B member 7 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serpin family B member 10 Neighboring gene serpin family B member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The expression of plasminogen activator system in a rat model of periodontal wound healing. Xiao Y, et al. J Periodontol, 2001 Jul. PMID 11495131
    2. Immunochemically detected placental proteins and their biological functions. Bohn H, et al. Arch Gynecol Obstet, 1991. PMID 1772263
    3. Basic mechanisms and regulation of fibrinolysis. Longstaff C, et al. J Thromb Haemost, 2015 Jun. PMID 26149056
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    plasminogen activator inhibitor 2 type A
    Names
    PAI-2
    serine (or cysteine) peptidase inhibitor, clade B, member 2
    serine (or cysteine) proteinase inhibitor, clade B, member 2
    serpin B2
    serpin peptidase inhibitor, clade B (ovalbumin), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021696.2 → NP_067728.1  plasminogen activator inhibitor 2 type A

      See identical proteins and their annotated locations for NP_067728.1

      Status: PROVISIONAL

      Source sequence(s)
      X64563
      UniProtKB/Swiss-Prot
      P29524
      UniProtKB/TrEMBL
      A6JSV9
      Related
      ENSRNOP00000003409.4, ENSRNOT00000003409.7
      Conserved Domains (1) summary
      cd19562
      Location:2 → 416
      serpinB2_PAI-2; serpin family B member 2, plasminogen activator inhibitor 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      24051933..24065032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769495.4 → XP_008767717.1  plasminogen activator inhibitor 2 type A isoform X1

      See identical proteins and their annotated locations for XP_008767717.1

      UniProtKB/Swiss-Prot
      P29524
      UniProtKB/TrEMBL
      A6JSV9
      Conserved Domains (1) summary
      cd19562
      Location:2 → 416
      serpinB2_PAI-2; serpin family B member 2, plasminogen activator inhibitor 2

    2. XM_006249639.5 → XP_006249701.1  plasminogen activator inhibitor 2 type A isoform X1

      See identical proteins and their annotated locations for XP_006249701.1

      UniProtKB/Swiss-Prot
      P29524
      UniProtKB/TrEMBL
      A6JSV9
      Conserved Domains (1) summary
      cd19562
      Location:2 → 416
      serpinB2_PAI-2; serpin family B member 2, plasminogen activator inhibitor 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29524.1 GenPept UniProtKB/Swiss-Prot:P29524

    Gene LinkOut

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