Add1 adducin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Add1provided by RGD
Official Full Name: adducin 1provided by RGD
Primary source: RGD:2041
See related: EnsemblRapid:ENSRNOG00000013039 AllianceGenome:RGD:2041
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables T cell receptor binding activity. Involved in several processes, including cellular response to retinoic acid; negative regulation of actin filament polymerization; and positive regulation of angiogenesis. Located in dendritic spine and perinuclear region of cytoplasm. Used to study hypertension. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 602.0), Brain (RPKM 405.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (80333242..80401641, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (76108643..76167267, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (81367466..81426610, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered expression of renal aquaporins and alpha-adducin polymorphisms may contribute to the establishment of salt-sensitive hypertension.
Title: Altered expression of renal aquaporins and α-adducin polymorphisms may contribute to the establishment of salt-sensitive hypertension.
The constitutive reduction of the Na/K pump endocytic rate induced by mutated adducin variants may be relevant in Na-dependent hypertension.
Title: alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption.
overexpression of wild type alpha adducin (WT-Add1) in endothelial cells induced capillary-like structure development
Title: Role of rat alpha adducin in angiogenesis: null effect of the F316Y polymorphism.
Reorganization of the unique cytoskeletal network defining a primary quiescent T cell is mediated thru the TCR-dependent modification & downregulation of alpha-adducin, resulting in a cytoskeletal shape compatible with T cell effector & memory functions.
Title: Identification of the cytoskeletal regulatory protein alpha-adducin as a target of T cell receptor signaling.
Add1 has a role in regulating blood pressure
Title: Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127695 (e-PCR)
- UniSTS:211005

BF397471 (e-PCR)
- UniSTS:246180

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in hemoglobin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemoglobin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in homeostasis of number of cells within a tissue	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of establishment of endothelial barrier	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-adducin

Names: adducin 1 (alpha); alpha-ADD; erythrocyte adducin subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016990.2 → NP_058686.2 alpha-adducin

See identical proteins and their annotated locations for NP_058686.2

Status: PROVISIONAL

Source sequence(s)

BC107657

UniProtKB/Swiss-Prot

Q3B7D4, Q63028, Q64722

UniProtKB/TrEMBL

A6IK25

Related

ENSRNOP00000018072.5, ENSRNOT00000018073.9

Conserved Domains (2) summary

pfam05934
Location:592 → 693

MCLC; Mid-1-related chloride channel (MCLC)

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

80333242..80401641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272840.1 → XP_063128910.1 alpha-adducin isoform X1

UniProtKB/TrEMBL

A6IK25
XM_063272849.1 → XP_063128919.1 alpha-adducin isoform X21

UniProtKB/TrEMBL

A6IK25
XM_039091611.2 → XP_038947539.1 alpha-adducin isoform X20

UniProtKB/TrEMBL

A6IK25, A6IK28

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006251161.3 → XP_006251223.1 alpha-adducin isoform X4

UniProtKB/TrEMBL

A6IK25

Conserved Domains (2) summary

pfam05934
Location:623 → 724

MCLC; Mid-1-related chloride channel (MCLC)

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272843.1 → XP_063128913.1 alpha-adducin isoform X12

UniProtKB/TrEMBL

A6IK25
XM_039091609.2 → XP_038947537.1 alpha-adducin isoform X14

UniProtKB/TrEMBL

A6IK25

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272841.1 → XP_063128911.1 alpha-adducin isoform X5

UniProtKB/TrEMBL

A6IK25
XM_063272847.1 → XP_063128917.1 alpha-adducin isoform X18

UniProtKB/TrEMBL

A6IK25
XM_063272848.1 → XP_063128918.1 alpha-adducin isoform X19

UniProtKB/TrEMBL

A6IK25
XM_006251159.3 → XP_006251221.1 alpha-adducin isoform X2

UniProtKB/TrEMBL

A6IK25, D3ZZ99

Related

ENSRNOP00000018340.6, ENSRNOT00000018340.7

Conserved Domains (2) summary

pfam05934
Location:638 → 739

MCLC; Mid-1-related chloride channel (MCLC)

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272842.1 → XP_063128912.1 alpha-adducin isoform X10

UniProtKB/TrEMBL

A6IK25
XM_006251160.4 → XP_006251222.1 alpha-adducin isoform X3

UniProtKB/TrEMBL

A6IK25

Related

ENSRNOP00000077285.2, ENSRNOT00000100756.2

Conserved Domains (2) summary

pfam05934
Location:623 → 724

MCLC; Mid-1-related chloride channel (MCLC)

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272845.1 → XP_063128915.1 alpha-adducin isoform X15

UniProtKB/TrEMBL

A6IK25
XM_006251165.4 → XP_006251227.1 alpha-adducin isoform X11

See identical proteins and their annotated locations for XP_006251227.1

UniProtKB/TrEMBL

A0A8I5Y1E2, A6IK25

Related

ENSRNOP00000103804.1, ENSRNOT00000137819.1

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272844.1 → XP_063128914.1 alpha-adducin isoform X13

UniProtKB/TrEMBL

A0A8I5Y1E2, A6IK25
XM_017599064.3 → XP_017454553.1 alpha-adducin isoform X1

UniProtKB/TrEMBL

A6IK25

Related

ENSRNOP00000094525.2, ENSRNOT00000098266.2
XM_017599066.3 → XP_017454555.1 alpha-adducin isoform X8

UniProtKB/TrEMBL

A6IK25

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_017599065.3 → XP_017454554.1 alpha-adducin isoform X6

UniProtKB/TrEMBL

A6IK25

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_039091605.2 → XP_038947533.1 alpha-adducin isoform X7

UniProtKB/TrEMBL

A6IK25

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272850.1 → XP_063128920.1 alpha-adducin isoform X22

UniProtKB/TrEMBL

A6IK25
XM_006251167.4 → XP_006251229.1 alpha-adducin isoform X17

UniProtKB/TrEMBL

A0A8I6ALT1, A6IK25

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_063272846.1 → XP_063128916.1 alpha-adducin isoform X16

UniProtKB/TrEMBL

A6IK25
XM_039091606.2 → XP_038947534.1 alpha-adducin isoform X9

UniProtKB/TrEMBL

A6IK25

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...