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    Prrx2 paired related homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113931, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prrx2provided by RGD
    Official Full Name
    paired related homeobox 2provided by RGD
    Primary source
    RGD:1311471
    See related
    EnsemblRapid:ENSRNOG00000058329 AllianceGenome:RGD:1311471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prx2
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II general transcription initiation factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic morphogenesis; positive regulation of cell population proliferation; and positive regulation of smoothened signaling pathway. Predicted to be active in nucleus. Orthologous to human PRRX2 (paired related homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 18.0), Uterus (RPKM 17.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Prrx2 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34530331..34566284)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14132574..14168533)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9681871..9718051)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene ankyrin repeat and SOCS box-containing 6 Neighboring gene prostaglandin E synthase Neighboring gene torsin family 1, member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within artery morphogenesis  
    acts_upstream_of_or_within cartilage development  
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis  
    acts_upstream_of_or_within embryonic limb morphogenesis  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis  
    acts_upstream_of_or_within inner ear morphogenesis  
    acts_upstream_of mesenchymal cell proliferation  
    acts_upstream_of_or_within middle ear morphogenesis  
    acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation  
    acts_upstream_of_or_within positive regulation of smoothened signaling pathway  
    acts_upstream_of_or_within positive regulation of stem cell proliferation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of smoothened signaling pathway  
    acts_upstream_of stem cell proliferation  
    involved_in transcription by RNA polymerase II  
    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    paired mesoderm homeobox protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415156.1 → NP_001402085.1  paired mesoderm homeobox protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JXV9
      Related
      ENSRNOP00000070422.2, ENSRNOT00000083251.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34530331..34566284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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