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    Adgrg1 adhesion G protein-coupled receptor G1 [ Mus musculus (house mouse) ]

    Gene ID: 14766, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adgrg1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor G1provided by MGI
    Primary source
    MGI:MGI:1340051
    See related
    Ensembl:ENSMUSG00000031785 AllianceGenome:MGI:1340051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyt28; Gpr56; TM7LN4; TM7XN1
    Summary
    Enables several functions, including collagen binding activity; extracellular matrix binding activity; and heparin binding activity. Involved in several processes, including negative regulation of neuron migration; positive regulation of Rho protein signal transduction; and seminiferous tubule development. Acts upstream of or within cerebral cortex regionalization; hematopoietic stem cell homeostasis; and positive regulation of neural precursor cell proliferation. Located in glial limiting end-foot. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in bilateral frontoparietal polymicrogyria and bilateral perisylvian polymicrogyria. Orthologous to human ADGRG1 (adhesion G protein-coupled receptor G1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 93.7), ovary adult (RPKM 80.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrg1 in Genome Data Viewer
    Location:
    8 C5; 8 47.12 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95701321..95740836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94974756..95014208)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene adhesion G protein-coupled receptor G5 Neighboring gene STARR-positive B cell enhancer ABC_E8258 Neighboring gene STARR-positive B cell enhancer ABC_E3795 Neighboring gene predicted gene, 30968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97500803-97501004 Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene dynein regulatory complex subunit 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Rao TN, et al. Stem Cell Res, 2015 May. PMID 25840412, Free PMC Article
    2. 57R2A, a newly established monoclonal antibody against mouse GPR56, marks long-term repopulating hematopoietic stem cells. Tokoro Y, et al. Exp Hematol, 2018 Mar. PMID 29225194
    3. Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Salzman GS, et al. Neuron, 2016 Sep 21. PMID 27657451, Free PMC Article
    4. Disease-associated mutations affect GPR56 protein trafficking and cell surface expression. Jin Z, et al. Hum Mol Genet, 2007 Aug 15. PMID 17576745
    5. Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation. Sasaki SI, et al. Cancer Sci, 2021 Dec. PMID 34632664, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in Glomerular Endothelial Cells.
      Title: GPR56 Promotes Diabetic Kidney Disease Through eNOS Regulation in Glomerular Endothelial Cells.
    2. Role of GPR56 in Platelet Activation and Arterial Thrombosis.
      Title: Role of GPR56 in Platelet Activation and Arterial Thrombosis.
    3. GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
      Title: GPR56 C-terminal fragment mediates signal received by N-terminal fragment of another adhesion GPCR Latrophilin1 in neurons.
    4. GPR56 S4 variant is required for microglia-mediated synaptic pruning.
      Title: GPR56 S4 variant is required for microglia-mediated synaptic pruning.
    5. Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation.
      Title: Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation.
    6. Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
      Title: Crucial contribution of GPR56/ADGRG1, expressed by breast cancer cells, to bone metastasis formation.
    7. Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
      Title: Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
    8. The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo.
      Title: The Inhibitory Receptor GPR56 (Adgrg1) Is Specifically Expressed by Tissue-Resident Memory T Cells in Mice But Dispensable for Their Differentiation and Function In Vivo.
    9. Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
      Title: Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation.
    10. A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
      Title: A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables extracellular matrix binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex radial glia-guided migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebral cortex regionalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in layer formation in cerebral cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glial limiting end-foot IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G1
    Names
    G-protein coupled receptor 56
    secretin receptor
    serpentine receptor cyt28
    NP_001185823.1
    NP_001390693.1
    NP_001390694.1
    NP_001390695.1
    NP_001390696.1
    NP_001390697.1
    NP_001390698.1
    NP_001390699.1
    NP_001390700.1
    NP_001390701.1
    NP_001390705.1
    NP_001390707.1
    NP_001390708.1
    NP_001390709.1
    NP_001390710.1
    NP_001390711.1
    NP_001390712.1
    NP_001390713.1
    NP_001390714.1
    NP_001390715.1
    NP_001390716.1
    NP_001390717.1
    NP_001390718.1
    NP_001390719.1
    NP_061370.2
    XP_006530752.1
    XP_006530754.1
    XP_006530760.1
    XP_017168066.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198894.2 → NP_001185823.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC103935, AC129606
      Consensus CDS
      CCDS22553.1
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2
      Related
      ENSMUSP00000137520.2, ENSMUST00000179619.9
      Conserved Domains (5) summary
      cd14964
      Location:403 → 427
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:345 → 388
      GPS; GPCR proteolysis site, GPS, motif
      pfam18587
      Location:29 → 162
      PLL; PTX/LNS-Like (PLL) domain
      pfam18619
      Location:173 → 220
      GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
      cl28897
      Location:400 → 667
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001403764.1 → NP_001390693.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935, AC129606

    3. NM_001403765.1 → NP_001390694.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935, AC129606

    4. NM_001403766.1 → NP_001390695.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    5. NM_001403767.1 → NP_001390696.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    6. NM_001403768.1 → NP_001390697.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    7. NM_001403769.1 → NP_001390698.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    8. NM_001403770.1 → NP_001390699.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    9. NM_001403771.1 → NP_001390700.1  adhesion G-protein coupled receptor G1 isoform a precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    10. NM_001403772.1 → NP_001390701.1  adhesion G-protein coupled receptor G1 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    11. NM_001403776.1 → NP_001390705.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935, AC129606
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    12. NM_001403778.1 → NP_001390707.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    13. NM_001403779.1 → NP_001390708.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    14. NM_001403780.1 → NP_001390709.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    15. NM_001403781.1 → NP_001390710.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    16. NM_001403782.1 → NP_001390711.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    17. NM_001403783.1 → NP_001390712.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    18. NM_001403784.1 → NP_001390713.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935, AC129606
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    19. NM_001403785.1 → NP_001390714.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935, AC129606
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    20. NM_001403786.1 → NP_001390715.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    21. NM_001403787.1 → NP_001390716.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    22. NM_001403788.1 → NP_001390717.1  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2

    23. NM_001403789.1 → NP_001390718.1  adhesion G-protein coupled receptor G1 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    24. NM_001403790.1 → NP_001390719.1  adhesion G-protein coupled receptor G1 isoform d precursor

      Status: VALIDATED

      Source sequence(s)
      AC103935

    25. NM_018882.4 → NP_061370.2  adhesion G-protein coupled receptor G1 isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC103935
      Consensus CDS
      CCDS22553.1
      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2
      Related
      ENSMUSP00000090959.7, ENSMUST00000093271.8
      Conserved Domains (5) summary
      cd14964
      Location:403 → 427
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:345 → 388
      GPS; GPCR proteolysis site, GPS, motif
      pfam18587
      Location:29 → 162
      PLL; PTX/LNS-Like (PLL) domain
      pfam18619
      Location:173 → 220
      GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
      cl28897
      Location:400 → 667
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95701321..95740836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530697.3 → XP_006530760.1  adhesion G-protein coupled receptor G1 isoform X7

      UniProtKB/Swiss-Prot
      Q3UR17, Q8K209, Q9QZT2
      Conserved Domains (5) summary
      cd14964
      Location:403 → 427
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:345 → 388
      GPS; GPCR proteolysis site, GPS, motif
      pfam18587
      Location:29 → 162
      PLL; PTX/LNS-Like (PLL) domain
      pfam18619
      Location:173 → 220
      GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
      cl28897
      Location:400 → 667
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006530691.5 → XP_006530754.1  adhesion G-protein coupled receptor G1 isoform X6

      Conserved Domains (5) summary
      cd14964
      Location:407 → 432
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:350 → 393
      GPS; GPCR proteolysis site, GPS, motif
      pfam18587
      Location:34 → 167
      PLL; PTX/LNS-Like (PLL) domain
      pfam18619
      Location:178 → 225
      GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
      cl28897
      Location:405 → 672
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_006530689.4 → XP_006530752.1  adhesion G-protein coupled receptor G1 isoform X6

      Conserved Domains (5) summary
      cd14964
      Location:407 → 432
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:350 → 393
      GPS; GPCR proteolysis site, GPS, motif
      pfam18587
      Location:34 → 167
      PLL; PTX/LNS-Like (PLL) domain
      pfam18619
      Location:178 → 225
      GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
      cl28897
      Location:405 → 672
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_017312577.2 → XP_017168066.1  adhesion G-protein coupled receptor G1 isoform X5

      Conserved Domains (5) summary
      cd14964
      Location:415 → 440
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:358 → 401
      GPS; GPCR proteolysis site, GPS, motif
      pfam18587
      Location:42 → 175
      PLL; PTX/LNS-Like (PLL) domain
      pfam18619
      Location:186 → 233
      GAIN_A; GPCR-Autoproteolysis-INducing (GAIN) subdomain A
      cl28897
      Location:413 → 680
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K209.1 GenPept UniProtKB/Swiss-Prot:Q8K209

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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