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    Ankzf1 ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankzf1provided by RGD
    Official Full Name
    ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1provided by RGD
    Primary source
    RGD:1359242
    See related
    EnsemblRapid:ENSRNOG00000019052 AllianceGenome:RGD:1359242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359242
    Summary
    Predicted to enable RNA endonuclease activity and catalytic activity, acting on a tRNA. Predicted to be involved in cellular response to hydrogen peroxide; proteolysis involved in protein catabolic process; and rescue of stalled ribosome. Predicted to be located in cytoplasm. Orthologous to human ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 167.3), Adrenal (RPKM 146.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankzf1 in Genome Data Viewer
    Location:
    9q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84136862..84143830)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76688194..76695162)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82393619..82400537)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 6 Neighboring gene autophagy related 9A Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene uncharacterized LOC102554903 Neighboring gene tubulin, alpha 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ankyrin repeat and zinc-finger domain-containing 1 mutations are associated with infantile-onset inflammatory bowel disease. van Haaften-Visser DY, et al. J Biol Chem, 2017 May 12. PMID 28302725, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables catalytic activity, acting on a tRNA ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA endonuclease ANKZF1
    Names
    ankyrin repeat and zinc finger domain containing 1
    ankyrin repeat and zinc finger domain-containing protein 1
    ankyrin repeat containing protein RGD1359242

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014219.2 → NP_001014241.2  tRNA endonuclease ANKZF1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q66H85
      UniProtKB/TrEMBL
      A0A8L2QKJ1, A6JVY8
      Related
      ENSRNOP00000036500.6, ENSRNOT00000032419.6
      Conserved Domains (8) summary
      PTZ00322
      Location:557 → 629
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      smart00451
      Location:95 → 127
      ZnF_U1; U1-like zinc finger
      sd00020
      Location:98 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00045
      Location:517 → 547
      ANK; ANK repeat [structural motif]
      pfam00023
      Location:557 → 587
      Ank; Ankyrin repeat
      pfam12796
      Location:520 → 587
      Ank_2; Ankyrin repeats (3 copies)
      pfam18716
      Location:705 → 746
      VATC; Vms1-associating treble clef domain
      pfam18826
      Location:231 → 375
      bVLRF1; bacteroidetes VLRF1 release factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84136862..84143830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267411.1 → XP_063123481.1  tRNA endonuclease ANKZF1 isoform X2

      UniProtKB/Swiss-Prot
      Q66H85

    2. XM_006245248.3 → XP_006245310.1  tRNA endonuclease ANKZF1 isoform X1

      UniProtKB/Swiss-Prot
      Q66H85
      Related
      ENSRNOP00000111906.1, ENSRNOT00000139430.1
      Conserved Domains (4) summary
      cd00204
      Location:505 → 567
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00020
      Location:98 → 120
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13857
      Location:484 → 545
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:465 → 495
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_005488937.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H85.1 GenPept UniProtKB/Swiss-Prot:Q66H85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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