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    Myo10 myosin X [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo10provided by RGD
    Official Full Name
    myosin Xprovided by RGD
    Primary source
    RGD:1307193
    See related
    EnsemblRapid:ENSRNOG00000010161 AllianceGenome:RGD:1307193
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytoskeletal protein binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in cytoskeleton-dependent intracellular transport; regulation of cell shape; and regulation of filopodium assembly. Predicted to act upstream of or within positive regulation of cell-cell adhesion. Predicted to be located in several cellular components, including filopodium tip; neuronal cell body; and nucleolus. Predicted to be part of myosin complex. Predicted to be active in filopodium. Orthologous to human MYO10 (myosin X). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 369.3), Kidney (RPKM 227.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo10 in Genome Data Viewer
    Location:
    2q22
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (77831532..78036137)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (76100989..76305619)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (77868398..78072443)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CWC15 spliceosome-associated protein, pseudogene 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC134485861 Neighboring gene uncharacterized LOC108349968 Neighboring gene reticulophagy regulator 1 Neighboring gene 60S ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Myosin-X is a molecular motor that functions in filopodia formation. Bohil AB, et al. Proc Natl Acad Sci U S A, 2006 Aug 15. PMID 16894163, Free PMC Article
    2. Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons. Sousa AD, et al. J Cell Sci, 2006 Jan 1. PMID 16371656
    3. Myosin X is a downstream effector of PI(3)K during phagocytosis. Cox D, et al. Nat Cell Biol, 2002 Jul. PMID 12055636
    4. Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Uchiyama Y, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439720, Free PMC Article
    5. The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Papal S, et al. Hum Mol Genet, 2013 Sep 15. PMID 23704327

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables plus-end directed microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end directed microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent intracellular transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in filopodium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-X
    Names
    unconventional myosin-10
    unconventionnal myosin-X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401822.1 → NP_001388751.1  unconventional myosin-X

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      D3ZJP6
      UniProtKB/TrEMBL
      A0A8I6AR40
      Related
      ENSRNOP00000063102.2, ENSRNOT00000065897.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      77831532..78036137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102214.2 → XP_038958142.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6
      Conserved Domains (10) summary
      smart00139
      Location:908 → 1054
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1063 → 1317
      B41; Band 4.1 homologues
      COG5022
      Location:2 → 288
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:1313 → 1401
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:574 → 675
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:740 → 865
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:1056 → 1151
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      NF033845
      Location:345 → 527
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl17171
      Location:540 → 582
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain

    2. XM_039102215.2 → XP_038958143.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6
      Conserved Domains (10) summary
      smart00139
      Location:908 → 1054
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1063 → 1317
      B41; Band 4.1 homologues
      COG5022
      Location:2 → 288
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:1313 → 1401
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:574 → 675
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:740 → 865
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:1056 → 1151
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      NF033845
      Location:345 → 527
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl17171
      Location:540 → 582
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain

    3. XM_039102218.2 → XP_038958146.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6
      Conserved Domains (10) summary
      smart00139
      Location:908 → 1054
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1063 → 1317
      B41; Band 4.1 homologues
      COG5022
      Location:2 → 288
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:1313 → 1401
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:574 → 675
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:740 → 865
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:1056 → 1151
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      NF033845
      Location:345 → 527
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl17171
      Location:540 → 582
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain

    4. XM_039102216.2 → XP_038958144.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6
      Conserved Domains (10) summary
      smart00139
      Location:908 → 1054
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1063 → 1317
      B41; Band 4.1 homologues
      COG5022
      Location:2 → 288
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:1313 → 1401
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:574 → 675
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:740 → 865
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:1056 → 1151
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      NF033845
      Location:345 → 527
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl17171
      Location:540 → 582
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:1 → 84
      Motor_domain; Myosin and Kinesin motor domain

    5. XM_063281749.1 → XP_063137819.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6

    6. XM_039102213.2 → XP_038958141.1  unconventional myosin-X isoform X1

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6
      Conserved Domains (10) summary
      smart00139
      Location:909 → 1055
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:1064 → 1318
      B41; Band 4.1 homologues
      COG5022
      Location:3 → 289
      COG5022; Myosin heavy chain [General function prediction only]
      cd13202
      Location:1314 → 1402
      FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
      cd13296
      Location:575 → 676
      PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
      cd13297
      Location:741 → 866
      PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
      cd17206
      Location:1057 → 1152
      FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
      NF033845
      Location:346 → 528
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl17171
      Location:541 → 583
      PH-like; Pleckstrin homology-like domain
      cl22853
      Location:2 → 85
      Motor_domain; Myosin and Kinesin motor domain

    7. XM_063281750.1 → XP_063137820.1  unconventional myosin-X isoform X2

      UniProtKB/TrEMBL
      A6JMW4, D3ZZ73, F1M9V6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107657.1: Suppressed sequence

      Description
      NM_001107657.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZJP6.1 GenPept UniProtKB/Swiss-Prot:D3ZJP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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