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    Inpp4a inositol polyphosphate-4-phosphatase, type I [ Mus musculus (house mouse) ]

    Gene ID: 269180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inpp4aprovided by MGI
    Official Full Name
    inositol polyphosphate-4-phosphatase, type Iprovided by MGI
    Primary source
    MGI:MGI:1931123
    See related
    Ensembl:ENSMUSG00000026113 AllianceGenome:MGI:1931123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    107kDa; 9630012D15; D130048C09Rik
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including cranium; facial prominence ectoderm; integumental system; nervous system; and urinary system. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 12.1), frontal lobe adult (RPKM 10.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Inpp4a in Genome Data Viewer
    Location:
    1 B; 1 15.46 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (37338908..37449821)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37299827..37410740)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene predicted gene, 37020 Neighboring gene STARR-seq mESC enhancer starr_00671 Neighboring gene STARR-seq mESC enhancer starr_00672 Neighboring gene STARR-seq mESC enhancer starr_00673 Neighboring gene STARR-seq mESC enhancer starr_00674 Neighboring gene cyclic nucleotide gated channel alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E788 Neighboring gene RIKEN cDNA 4930439A04 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:37374616-37374799 Neighboring gene STARR-seq mESC enhancer starr_00675 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Plausible role of INPP4A dysregulation in idiopathic pulmonary fibrosis. Arvind M, et al. Physiol Rep, 2024 May. PMID 38720166, Free PMC Article
    2. Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Vyas P, et al. Proc Natl Acad Sci U S A, 2000 Dec 5. PMID 11087841, Free PMC Article
    3. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. Shin HW, et al. J Cell Biol, 2005 Aug 15. PMID 16103228, Free PMC Article
    4. Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1. Ivetac I, et al. EMBO Rep, 2009 May. PMID 19325558, Free PMC Article
    5. Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A). Aich J, et al. Int Immunopharmacol, 2012 Dec. PMID 22986054

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plausible role of INPP4A dysregulation in idiopathic pulmonary fibrosis.
      Title: Plausible role of INPP4A dysregulation in idiopathic pulmonary fibrosis.
    2. Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
      Title: Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
    3. Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
      Title: Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity.
    4. MicroRNA-223-3p regulates allergic in fl ammation by targeting INPP4A.
      Title: MicroRNA-223-3p regulates allergic inflammation by targeting INPP4A.
    5. this study shows that the myeloid Inpp4a-knockout mice display impaired bacteria clearance due to decreased inflammatory cytokine production
      Title: Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model.
    6. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a, and accelerates phagosome acidification
      Title: Inhibitory receptor FcγRIIb mediates the effects of IgG on a phagosome acidification and a sequential dephosphorylation system comprising SHIPs and Inpp4a.
    7. This study showed that spontaneous Inpp4a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
      Title: Behavioral effects of neonatal lesions on the cerebellar system.
    8. These results suggest a novel mechanism of action of resveratrol in attenuating asthma phenotype by downregulating PI3K-Akt pathway via upregulating INPP4A.
      Title: Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A).
    9. INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death
      Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
    10. Purkinje cell loss in the Inpp4a(wbl) mutant is due to glutamate excitotoxicity initiated by the climbing fiber, and that Eaat4 may exert a protective effect.
      Title: Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables inositol-1,3,4-trisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-3,4-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polyphosphate catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate-4-phosphatase type I A
    Names
    4-Ptase-1
    inositol polyphosphate 4-phosphatase-1
    type I inositol 3,4-bisphosphate 4-phosphatase
    NP_001277726.1
    NP_001277727.1
    NP_001277728.1
    NP_001361558.1
    NP_001361559.1
    NP_084542.2
    NP_766559.2
    XP_006496069.1
    XP_006496071.1
    XP_006496072.1
    XP_006496073.1
    XP_006496074.1
    XP_006496077.1
    XP_006496078.1
    XP_006496079.1
    XP_006496080.1
    XP_006496081.1
    XP_006496082.1
    XP_030110502.1
    XP_030110505.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290797.1 → NP_001277726.1  inositol polyphosphate-4-phosphatase type I A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC084390, AC133096, AF317838, AK035867, AK149414, BY274715
      Consensus CDS
      CCDS69879.1
      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      UniProtKB/TrEMBL
      D3Z230
      Related
      ENSMUSP00000121803.2, ENSMUST00000137266.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    2. NM_001290798.1 → NP_001277727.1  inositol polyphosphate-4-phosphatase type I A isoform 4

      See identical proteins and their annotated locations for NP_001277727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC084390, AK035867
      Consensus CDS
      CCDS78570.1
      UniProtKB/TrEMBL
      A0A0R4J0Q2, B7ZMQ9
      Related
      ENSMUSP00000057233.9, ENSMUST00000058307.15

    3. NM_001290799.1 → NP_001277728.1  inositol polyphosphate-4-phosphatase type I A isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC084390, AK035867
      UniProtKB/TrEMBL
      B7ZMQ9
      Related
      ENSMUSP00000130443.3, ENSMUST00000168546.3

    4. NM_001374629.1 → NP_001361558.1  inositol polyphosphate-4-phosphatase type I A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC084390, AC133096
      Consensus CDS
      CCDS87820.1
      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      UniProtKB/TrEMBL
      D3YUL8
      Related
      ENSMUSP00000123071.2, ENSMUST00000132401.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    5. NM_001374630.1 → NP_001361559.1  inositol polyphosphate-4-phosphatase type I A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC084390, AC133096
      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    6. NM_030266.4 → NP_084542.2  inositol polyphosphate-4-phosphatase type I A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses several alternate in-frame splice sites in the coding region, compared to variant 3. The encoded protein (isoform 1) is shorter than isoform 3.
      Source sequence(s)
      AC084390, AC133096, AF317838, AK035867, AK149414, BY274715
      Consensus CDS
      CCDS35539.1
      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      UniProtKB/TrEMBL
      F6V2U0
      Related
      ENSMUSP00000027287.5, ENSMUST00000027287.11
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    7. NM_172971.3 → NP_766559.2  inositol polyphosphate-4-phosphatase type I A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 3. These differences include an alternate translation initiation start codon and an alternate 3' terminal exon. The encoded protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AC084390, AK035867
      Consensus CDS
      CCDS35540.1
      UniProtKB/TrEMBL
      E9QAD0, Q0VBQ7
      Related
      ENSMUSP00000110583.3, ENSMUST00000114933.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      37338908..37449821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496011.3 → XP_006496074.1  inositol polyphosphate-4-phosphatase type I A isoform X5

      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    2. XM_030254642.2 → XP_030110502.1  inositol polyphosphate-4-phosphatase type I A isoform X12

      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    3. XM_030254645.2 → XP_030110505.1  inositol polyphosphate-4-phosphatase type I A isoform X13

      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    4. XM_006496019.3 → XP_006496082.1  inositol polyphosphate-4-phosphatase type I A isoform X11

      UniProtKB/Swiss-Prot
      Q8CBJ8, Q9EPW0
      UniProtKB/TrEMBL
      E9Q9A0
      Related
      ENSMUSP00000121518.3, ENSMUST00000136846.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    5. XM_006496006.3 → XP_006496069.1  inositol polyphosphate-4-phosphatase type I A isoform X1

      See identical proteins and their annotated locations for XP_006496069.1

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    6. XM_006496014.3 → XP_006496077.1  inositol polyphosphate-4-phosphatase type I A isoform X6

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    7. XM_006496017.3 → XP_006496080.1  inositol polyphosphate-4-phosphatase type I A isoform X9

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    8. XM_006496018.3 → XP_006496081.1  inositol polyphosphate-4-phosphatase type I A isoform X10

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    9. XM_006496010.3 → XP_006496073.1  inositol polyphosphate-4-phosphatase type I A isoform X4

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    10. XM_006496008.3 → XP_006496071.1  inositol polyphosphate-4-phosphatase type I A isoform X2

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    11. XM_006496015.3 → XP_006496078.1  inositol polyphosphate-4-phosphatase type I A isoform X7

      UniProtKB/TrEMBL
      D3YTM1, D3YUD3, Q3UEQ1
      Related
      ENSMUSP00000115249.3, ENSMUST00000132615.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    12. XM_006496009.3 → XP_006496072.1  inositol polyphosphate-4-phosphatase type I A isoform X3

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    13. XM_006496016.5 → XP_006496079.1  inositol polyphosphate-4-phosphatase type I A isoform X8

      UniProtKB/TrEMBL
      D3YTM1, Q3UEQ1
      Related
      ENSMUSP00000121107.3, ENSMUST00000140264.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPW0.1 GenPept UniProtKB/Swiss-Prot:Q9EPW0

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