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    Neb nebulin [ Mus musculus (house mouse) ]

    Gene ID: 17996, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nebprovided by MGI
    Official Full Name
    nebulinprovided by MGI
    Primary source
    MGI:MGI:97292
    See related
    Ensembl:ENSMUSG00000026950 AllianceGenome:MGI:97292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cardiac muscle thin filament assembly. Predicted to act upstream of or within regulation of actin filament length and sarcomere organization. Located in Z disc. Is expressed in hindlimb muscle; palatal shelf; and trunk dermomyotome. Used to study nemaline myopathy 2. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-6 and nemaline myopathy 2. Orthologous to human NEB (nebulin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 5.3), limb E14.5 (RPKM 2.8) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Neb in Genome Data Viewer
    Location:
    2 C1.1; 2 29.98 cM
    Exon count:
    166
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52026652..52228810, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52136640..52338798, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor alpha induced protein 6 Neighboring gene STARR-seq mESC enhancer starr_04477 Neighboring gene replication timing regulatory factor 1 Neighboring gene STARR-seq mESC enhancer starr_04479 Neighboring gene RIKEN cDNA 4930573O16 gene Neighboring gene STARR-seq mESC enhancer starr_04480 Neighboring gene predicted gene 13521 Neighboring gene predicted gene 13522

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development. Buck D, et al. J Struct Biol, 2010 May. PMID 20176113, Free PMC Article
    2. Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle. Kiss B, et al. Proc Natl Acad Sci U S A, 2018 Oct 9. PMID 30249654, Free PMC Article
    3. Muscle weakness in respiratory and peripheral skeletal muscles in a mouse model for nebulin-based nemaline myopathy. Joureau B, et al. Neuromuscul Disord, 2017 Jan. PMID 27890461, Free PMC Article
    4. Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy. Li F, et al. Hum Mol Genet, 2015 Sep 15. PMID 26123491, Free PMC Article
    5. cDNA cloning of mouse nebulin. Evidence that the nebulin-coding sequence is highly conserved among vertebrates. Zhang JQ, et al. Eur J Biochem, 1996 Aug 1. PMID 8774733

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
      Title: Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
    2. NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy.
      Title: NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy.
    3. Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.
      Title: Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin.
    4. Bioinformatics Analysis and High-Throughput Sequencing to Identify Differentially Expressed Genes in Nebulin Gene (NEB) Mutations Mice.
      Title: Bioinformatics Analysis and High-Throughput Sequencing to Identify Differentially Expressed Genes in Nebulin Gene (NEB) Mutations Mice.
    5. Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb.
      Title: Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb.
    6. Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.
      Title: Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism.
    7. Study found that adult nebulin-deficient mice displayed severe muscle atrophy and weakness in vivo related to a low nebulin content but an improved fatigue resistance due to a slower contractile phenotype.
      Title: In vivo characterization of skeletal muscle function in nebulin-deficient mice.
    8. To study the functions of nebulin's C-terminus, we generated a mouse model deleting the final two unique C-terminal domains, the serine-rich region (SRR) and the SH3 domain (NebDelta163-165).
      Title: Deleting nebulin's C-terminus reveals its importance to sarcomeric structure and function and is sufficient to invoke nemaline myopathy.
    9. Muscle fibers are weak in the absence of Neb, in particular when large tension develops, which may structurally damage the thin filament when Neb is absent.
      Title: Nebulin increases thin filament stiffness and force per cross-bridge in slow-twitch soleus muscle fibers.
    10. Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity
      Title: Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cardiac muscle thin filament assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin filament length TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within sarcomere organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in contractile muscle fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in striated muscle thin filament TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nebulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010889.1 → NP_035019.1  nebulin

      Status: VALIDATED

      Source sequence(s)
      AL844571, AL845355
      Consensus CDS
      CCDS50584.1
      UniProtKB/TrEMBL
      A2AQA9, E9Q1W3
      Related
      ENSMUSP00000047763.6, ENSMUST00000036934.12
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7095 → 7152
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:1103 → 1129
      Nebulin; Nebulin repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      52026652..52228810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159260.1 → XP_036015153.1  nebulin isoform X34

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:3909 → 3939
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7188 → 7245
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:4886 → 4913
      Nebulin; Nebulin repeat

    2. XM_036159285.1 → XP_036015178.1  nebulin isoform X48

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:3666 → 3696
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:6945 → 7002
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:4643 → 4670
      Nebulin; Nebulin repeat

    3. XM_036159259.1 → XP_036015152.1  nebulin isoform X33

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:3909 → 3939
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7188 → 7245
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:4886 → 4913
      Nebulin; Nebulin repeat

    4. XM_036159258.1 → XP_036015151.1  nebulin isoform X32

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:3909 → 3939
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7188 → 7245
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:4886 → 4913
      Nebulin; Nebulin repeat

    5. XM_036159255.1 → XP_036015148.1  nebulin isoform X31

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:3909 → 3939
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7188 → 7245
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:4886 → 4913
      Nebulin; Nebulin repeat

    6. XM_036159284.1 → XP_036015177.1  nebulin isoform X47

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:3666 → 3696
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:6945 → 7002
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:4643 → 4670
      Nebulin; Nebulin repeat

    7. XM_036159275.1 → XP_036015168.1  nebulin isoform X43

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7142 → 7199
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    8. XM_036159276.1 → XP_036015169.1  nebulin isoform X44

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7142 → 7199
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    9. XM_036159273.1 → XP_036015166.1  nebulin isoform X42

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7146 → 7203
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    10. XM_036159271.1 → XP_036015164.1  nebulin isoform X41

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7146 → 7203
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    11. XM_036159248.1 → XP_036015141.1  nebulin isoform X30

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7208 → 7265
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    12. XM_036159214.1 → XP_036015107.1  nebulin isoform X11

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7394 → 7451
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    13. XM_036159277.1 → XP_036015170.1  nebulin isoform X45

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7141 → 7198
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    14. XM_036159279.1 → XP_036015172.1  nebulin isoform X46

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7141 → 7198
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    15. XM_036159235.1 → XP_036015128.1  nebulin isoform X25

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (4) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      PTZ00121
      Location:6434 → 6863
      PTZ00121; MAEBL; Provisional
      cd11933
      Location:7238 → 7295
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    16. XM_036159216.1 → XP_036015109.1  nebulin isoform X12

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7393 → 7450
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    17. XM_036159269.1 → XP_036015162.1  nebulin isoform X40

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (4) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      PTZ00121
      Location:6434 → 6971
      PTZ00121; MAEBL; Provisional
      cd11933
      Location:7148 → 7205
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    18. XM_036159268.1 → XP_036015161.1  nebulin isoform X39

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7148 → 7205
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    19. XM_036159265.1 → XP_036015158.1  nebulin isoform X37

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (4) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      PTZ00121
      Location:6434 → 6997
      PTZ00121; MAEBL; Provisional
      cd11933
      Location:7179 → 7236
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    20. XM_036159211.1 → XP_036015104.1  nebulin isoform X10

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (4) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      PTZ00121
      Location:6434 → 6976
      PTZ00121; MAEBL; Provisional
      cd11933
      Location:7396 → 7453
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    21. XM_036159242.1 → XP_036015135.1  nebulin isoform X29

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7214 → 7271
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    22. XM_036159266.1 → XP_036015159.1  nebulin isoform X38

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7152 → 7209
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    23. XM_036159264.1 → XP_036015157.1  nebulin isoform X36

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7183 → 7240
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    24. XM_036159262.1 → XP_036015155.1  nebulin isoform X35

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7183 → 7240
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    25. XM_036159236.1 → XP_036015129.1  nebulin isoform X26

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7214 → 7271
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    26. XM_036159228.1 → XP_036015121.1  nebulin isoform X21

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7245 → 7302
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    27. XM_036159200.1 → XP_036015093.1  nebulin isoform X6

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    28. XM_036159239.1 → XP_036015132.1  nebulin isoform X28

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7214 → 7271
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    29. XM_036159233.1 → XP_036015126.1  nebulin isoform X23

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7245 → 7302
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    30. XM_036159238.1 → XP_036015131.1  nebulin isoform X27

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7214 → 7271
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    31. XM_036159231.1 → XP_036015124.1  nebulin isoform X22

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7245 → 7302
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    32. XM_036159227.1 → XP_036015120.1  nebulin isoform X19

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7276 → 7333
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    33. XM_036159226.1 → XP_036015119.1  nebulin isoform X18

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7307 → 7364
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    34. XM_036159220.1 → XP_036015113.1  nebulin isoform X16

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7338 → 7395
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    35. XM_036159198.1 → XP_036015091.1  nebulin isoform X5

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    36. XM_036159234.1 → XP_036015127.1  nebulin isoform X24

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7245 → 7302
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    37. XM_017316181.2 → XP_017171670.1  nebulin isoform X15

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7338 → 7395
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5131 → 5157
      Nebulin; Nebulin repeat

    38. XM_036159217.1 → XP_036015110.1  nebulin isoform X13

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7369 → 7426
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    39. XM_036159196.1 → XP_036015089.1  nebulin isoform X3

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    40. XM_036159197.1 → XP_036015090.1  nebulin isoform X4

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    41. XM_036159218.1 → XP_036015111.1  nebulin isoform X14

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7369 → 7426
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    42. XM_036159203.1 → XP_036015096.1  nebulin isoform X7

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    43. XM_036159208.1 → XP_036015101.1  nebulin isoform X8

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    44. XM_036159192.1 → XP_036015085.1  nebulin isoform X1

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7431 → 7488
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    45. XM_006497760.2 → XP_006497823.1  nebulin isoform X20

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7276 → 7333
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5131 → 5157
      Nebulin; Nebulin repeat

    46. XM_036159210.1 → XP_036015103.1  nebulin isoform X9

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7400 → 7457
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    47. XM_006497749.2 → XP_006497812.1  nebulin isoform X17

      See identical proteins and their annotated locations for XP_006497812.1

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7338 → 7395
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5131 → 5157
      Nebulin; Nebulin repeat

    48. XM_036159195.1 → XP_036015088.1  nebulin isoform X2

      UniProtKB/TrEMBL
      A0A571BF46, A2AQA9
      Related
      ENSMUSP00000158760.2, ENSMUST00000238288.2
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7431 → 7488
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat

    49. XM_006497776.2 → XP_006497839.1  nebulin isoform X49

      UniProtKB/TrEMBL
      A0A571BF58, A2AQA9
      Related
      ENSMUSP00000158777.2, ENSMUST00000238749.2
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7466 → 7523
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5131 → 5157
      Nebulin; Nebulin repeat

    50. XM_036159194.1 → XP_036015087.1  nebulin isoform X1

      UniProtKB/TrEMBL
      A2AQA9
      Conserved Domains (3) summary
      smart00227
      Location:4152 → 4182
      NEBU; The Nebulin repeat is present also in Las1
      cd11933
      Location:7431 → 7488
      SH3_Nebulin_C; C-terminal Src Homology 3 domain of Nebulin
      pfam00880
      Location:5129 → 5156
      Nebulin; Nebulin repeat
    Nucleotide Protein Strain
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