Mettl14 methyltransferase 14, N6-adenosine-methyltransferase subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl14provided by MGI
Official Full Name: methyltransferase 14, N6-adenosine-methyltransferase subunitprovided by MGI
Primary source: MGI:MGI:2442926
See related: Ensembl:ENSMUSG00000028114 AllianceGenome:MGI:2442926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1627; G430022H21Rik
Summary: Enables mRNA m(6)A methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and regulation of mRNA stability. Part of RNA N6-methyladenosine methyltransferase complex. Is active in nucleus. Is expressed in brain; hindlimb; intestine; and liver. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.1), CNS E14 (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 53.96 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (123161944..123179639, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (123368295..123385990, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Title: METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.
Title: METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.
METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression by up-regulating ADAM8.
Title: METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression by up-regulating ADAM8.
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Title: METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
The m[6]A methylation enzyme METTL14 regulates myocardial ischemia/reperfusion injury through the Akt/mTOR signaling pathway.
Title: The m(6)A methylation enzyme METTL14 regulates myocardial ischemia/reperfusion injury through the Akt/mTOR signaling pathway.
METTL14-mediated upregulation of lncRNA HOTAIR represses PP1alpha expression by promoting H3K4me1 demethylation in oxycodone-treated mice.
Title: METTL14-mediated upregulation of lncRNA HOTAIR represses PP1α expression by promoting H3K4me1 demethylation in oxycodone-treated mice.
Silencing METTL14 alleviates liver injury in non-alcoholic fatty liver disease by regulating mitochondrial homeostasis.
Title: Silencing METTL14 alleviates liver injury in non-alcoholic fatty liver disease by regulating mitochondrial homeostasis.
METTL14 regulates CD8[+]T-cell activation and immune responses to anti-PD-1 therapy in lung cancer.
Title: METTL14 regulates CD8(+)T-cell activation and immune responses to anti-PD-1 therapy in lung cancer.
METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes.
Title: METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes.
METTL14 downregulation drives S100A4[+] monocyte-derived macrophages via MyD88/NF-kappaB pathway to promote MAFLD progression.
Title: METTL14 downregulation drives S100A4(+) monocyte-derived macrophages via MyD88/NF-κB pathway to promote MAFLD progression.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

18.MMHAP27FLF3.seq (e-PCR)
- UniSTS:123377

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mRNA m(6)A methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA m(6)A methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA m(6)A methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA modification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA modification	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of RNA N6-methyladenosine methyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: N6-adenosine-methyltransferase non-catalytic subunit

Names: N6-adenosine-methyltransferase subunit METTL14; methyltransferase like 14; methyltransferase-like protein 14; snoRNA MBII-84

NP_964000.2

EC 2.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.