Ccr3 C-C motif chemokine receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccr3provided by MGI
Official Full Name: C-C motif chemokine receptor 3provided by MGI
Primary source: MGI:MGI:104616
See related: Ensembl:ENSMUSG00000035448 AllianceGenome:MGI:104616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CKR3; Cmkbr3; CC-CKR3; Cmkbr1l2
Summary: Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in positive regulation of angiogenesis and positive regulation of endothelial cell proliferation. Acts upstream of or within chemotaxis. Predicted to be located in endosome; extracellular space; and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in embryo and yolk sac. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 2.4), subcutaneous fat pad adult (RPKM 0.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 75.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (123817799..123831729)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (124017825..124031692)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.
Title: CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV.
CCR3 gene knockout inhibits proliferation, differentiation, and migration of eosinophils in allergic rhinitis model mice.
Title: CCR3 gene knockout inhibits proliferation, differentiation, and migration of eosinophils in allergic rhinitis model mice.
CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.
Title: CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain.
Lack of CCR3 leads to a skeletal phenotype only in male mice.
Title: Lack of CCR3 leads to a skeletal phenotype only in male mice.
Gene knockdown of CCR3 reduces eosinophilic inflammation and the Th2 immune response by inhibiting the PI3K/AKT pathway in allergic rhinitis mice.
Title: Gene knockdown of CCR3 reduces eosinophilic inflammation and the Th2 immune response by inhibiting the PI3K/AKT pathway in allergic rhinitis mice.
CCR3 gene knockout in bone marrow cells ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing airway inflammatory cell infiltration and Th2 cytokines expression in mice model.
Title: CCR3 gene knockout in bone marrow cells ameliorates combined allergic rhinitis and asthma syndrome (CARAS) by reducing airway inflammatory cell infiltration and Th2 cytokines expression in mice model.
Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain.
Title: Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain.
Lack of protective effect of CCR3 blockade during experimental colitis may be related to CCR3 expression by colonic Tregs.
Title: Lack of protective effect of CCR3 blockade during experimental colitis may be related to CCR3 expression by colonic Tregs.
Development of Anti-Mouse CC Chemokine Receptor 3 Monoclonal Antibodies for Flow Cytometry.
Title: Development of Anti-Mouse CC Chemokine Receptor 3 Monoclonal Antibodies for Flow Cytometry.
CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice.
Title: CCR3 deficiency is associated with increased osteoclast activity and reduced cortical bone volume in adult male mice.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC112554P1 (e-PCR)
- UniSTS:270233

NoName (e-PCR)
- UniSTS:224204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in angioblast cell migration	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable C-C chemokine receptor type 3

Names: C-C CKR-3; CC chemokine receptor 3; CC-CKR-3; CCR-3; MIP-1 alpha RL2; MIP-1 alphaRL2; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 1,-like 2; chemokine (C-C) receptor 3; macrophage inflammatory protein 1-alpha receptor-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009914.4 → NP_034044.3 probable C-C chemokine receptor type 3

See identical proteins and their annotated locations for NP_034044.3

Status: VALIDATED

Source sequence(s)

AC192862, AK041106, AK153518

Consensus CDS

CCDS23668.1

UniProtKB/Swiss-Prot

P51678, Q8K3M7

UniProtKB/TrEMBL

Q8BHB8

Related

ENSMUSP00000039107.8, ENSMUST00000039171.9

Conserved Domains (1) summary

cd15185
Location:39 → 316

7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

123817799..123831729

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313119.3 → XP_017168608.1 probable C-C chemokine receptor type 3 isoform X1

UniProtKB/Swiss-Prot

P51678, Q8K3M7

UniProtKB/TrEMBL

Q8BHB8

Conserved Domains (1) summary

cd15185
Location:39 → 316

7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors