Rbl2 RB transcriptional corepressor like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbl2provided by RGD
Official Full Name: RB transcriptional corepressor like 2provided by RGD
Primary source: RGD:3541
See related: EnsemblRapid:ENSRNOG00000012153 AllianceGenome:RGD:3541
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rb2
Summary: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression. Located in chromatin. Orthologous to human RBL2 (RB transcriptional corepressor like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 174.5), Kidney (RPKM 140.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (32049690..32096467, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (15876852..15923632, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (17300088..17346865, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RB2/P130 could be a marker of senescence or that it even plays a role in triggering the process in MSCs.
Title: In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes.
PPARalpha trans-repression involved the recruitment of the retinoblastoma (RB) family proteins p107 and p130 to the TERT promoter resulting in impaired E2F-1 binding, an effect that was dependent on p16.
Title: The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation.
Rb2 was found to have a role in neural differentiation but not in neural determination.
Title: Role of RB and RB2/P130 genes in marrow stromal stem cells plasticity.
p130-E2F4 complex recruits the chromatin modifiers HDAC1 and Suv39H1 to promote gene silencing and neuron survival.
Title: Regulation of neuron survival and death by p130 and associated chromatin modifiers.
data indicate that p53 can cooperate selectively with p130(Rb2) to induce cellular senescence, a pathway that may be relevant when the pRb/p16INK4a pathway is defunct
Title: Cooperation between p53 and p130(Rb2) in induction of cellular senescence.
RB2/p130 plays a role in the early neural differentiation of mysenchymal stem cells through histone deacetylases dependent pathways.
Title: RB and RB2/p130 genes demonstrate both specific and overlapping functions during the early steps of in vitro neural differentiation of marrow stromal stem cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142012 (e-PCR)
- UniSTS:224003

BE120467 (e-PCR)
- UniSTS:247338

RH132847 (e-PCR)
- UniSTS:216130

RH144576 (e-PCR)
- UniSTS:233821

BE112852 (e-PCR)
- UniSTS:246204

RH136737 (e-PCR)
- UniSTS:218826

RH137786 (e-PCR)
- UniSTS:219873

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinoblastoma-like protein 2

Names: 130 kDa retinoblastoma-associated protein; P130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RBR-2; retinoblastoma-like 2; retinoblastoma-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031094.2 → NP_112356.2 retinoblastoma-like protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

O55081

UniProtKB/TrEMBL

A6KD82

Related

ENSRNOP00000088993.1, ENSRNOT00000117469.2

Conserved Domains (5) summary

pfam01858
Location:414 → 606

RB_A; Retinoblastoma-associated protein A domain

pfam11934
Location:101 → 233

DUF3452; Domain of unknown function (DUF3452)

cd00043
Location:41 → 131

CYCLIN_SF; Cyclin box fold superfamily

cd20606
Location:831 → 1018

CYCLIN_RBL2; cyclin box found in retinoblastoma-like protein 2 (RBL2) and similar proteins

cl41773
Location:696 → 834

SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

32049690..32096467 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255199.5 → XP_006255261.1 retinoblastoma-like protein 2 isoform X1

UniProtKB/Swiss-Prot

O55081

UniProtKB/TrEMBL

G3V7P7

Related

ENSRNOP00000017361.3, ENSRNOT00000017361.5

Conserved Domains (4) summary

pfam01857
Location:831 → 1011

RB_B; Retinoblastoma-associated protein B domain

pfam01858
Location:414 → 606

RB_A; Retinoblastoma-associated protein A domain

pfam04518
Location:323 → 433

Effector_1; Effector from type III secretion system

pfam11934
Location:101 → 233

DUF3452; Domain of unknown function (DUF3452)
XM_006255200.5 → XP_006255262.1 retinoblastoma-like protein 2 isoform X2

UniProtKB/Swiss-Prot

O55081

Conserved Domains (4) summary

pfam01857
Location:831 → 921

RB_B; Retinoblastoma-associated protein B domain

pfam01858
Location:414 → 606

RB_A; Retinoblastoma-associated protein A domain

pfam04518
Location:323 → 433

Effector_1; Effector from type III secretion system

pfam11934
Location:101 → 233

DUF3452; Domain of unknown function (DUF3452)
XM_063278309.1 → XP_063134379.1 retinoblastoma-like protein 2 isoform X3