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    Aktip AKT interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aktipprovided by RGD
    Official Full Name
    AKT interacting proteinprovided by RGD
    Primary source
    RGD:1311170
    See related
    EnsemblRapid:ENSRNOG00000011956 AllianceGenome:RGD:1311170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fts
    Summary
    Predicted to enable NEDD8 transferase activity. Predicted to be involved in several processes, including early endosome to late endosome transport; protein localization to perinuclear region of cytoplasm; and protein neddylation. Predicted to act upstream of or within positive regulation of protein phosphorylation. Predicted to be located in plasma membrane. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in cytosol and nucleus. Orthologous to human AKTIP (AKT interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 378.8), Brain (RPKM 292.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aktip in Genome Data Viewer
    Location:
    19p11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (32039507..32059634)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (15866811..15877123)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (17290048..17300054)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Rpgrip1-like Neighboring gene uncharacterized LOC134483615 Neighboring gene RB transcriptional corepressor like 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene chromodomain helicase DNA binding protein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Xu L, et al. Mol Biol Cell, 2008 Dec. PMID 18799622, Free PMC Article
    2. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Remy I, et al. Mol Cell Biol, 2004 Feb. PMID 14749367, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109405

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endosome to lysosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FHF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of FHF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of FHF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of HOPS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of HOPS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AKT-interacting protein
    Names
    fused toes protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011926.1 → NP_001011926.1  AKT-interacting protein

      See identical proteins and their annotated locations for NP_001011926.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089985
      UniProtKB/Swiss-Prot
      Q5FVH4
      UniProtKB/TrEMBL
      A0A8I6GA43, A6KD80
      Related
      ENSRNOP00000105243.1, ENSRNOT00000143979.1
      Conserved Domains (1) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      32039507..32059634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601205.3 → XP_017456694.1  AKT-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GA43

    2. XM_017601206.2 → XP_017456695.1  AKT-interacting protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6GA43
      Related
      ENSRNOP00000082936.2, ENSRNOT00000113279.2

    3. XM_006255182.5 → XP_006255244.1  AKT-interacting protein isoform X3

      See identical proteins and their annotated locations for XP_006255244.1

      UniProtKB/TrEMBL
      A0A8I6AQ33, A0A8I6GA43
      Conserved Domains (2) summary
      smart00212
      Location:79 → 222
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
      COG5078
      Location:79 → 218
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

    4. XM_063277864.1 → XP_063133934.1  AKT-interacting protein isoform X4

      UniProtKB/Swiss-Prot
      Q5FVH4
      UniProtKB/TrEMBL
      A0A8I6GA43, A6KD80

    5. XM_063277863.1 → XP_063133933.1  AKT-interacting protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6AQ33, A0A8I6GA43
      Related
      ENSRNOP00000091269.1, ENSRNOT00000108713.2

    6. XM_063277865.1 → XP_063133935.1  AKT-interacting protein isoform X5

      UniProtKB/TrEMBL
      A0A8I6AI00, A0A8I6GA43, A6KD77
      Related
      ENSRNOP00000092612.1, ENSRNOT00000109943.2

    7. XM_039097569.2 → XP_038953497.1  AKT-interacting protein isoform X6

      Conserved Domains (1) summary
      smart00212
      Location:2 → 138
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVH4.1 GenPept UniProtKB/Swiss-Prot:Q5FVH4

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