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    pilT twitching motility protein PilT [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878389, updated on 24-Aug-2024

    Summary

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    Gene symbol
    pilT
    Gene description
    twitching motility protein PilT
    Locus tag
    PA0395
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (436570..437604)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene hypothetical protein Neighboring gene twitching motility protein PilU Neighboring gene cation efflux system protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. P. aeruginosa PilT structures with and without nucleotide reveal a dynamic type IV pilus retraction motor. Misic AM, et al. J Mol Biol, 2010 Jul 30. PMID 20595000, Free PMC Article
    2. The pilT gene contributes to type III ExoS effector injection into epithelial cells in Pseudomonas aeruginosa. Shikata M, et al. J Infect Chemother, 2016 Apr. PMID 26809217
    3. Functional role of conserved residues in the characteristic secretion NTPase motifs of the Pseudomonas aeruginosa type IV pilus motor proteins PilB, PilT and PilU. Chiang P, et al. Microbiology (Reading), 2008 Jan. PMID 18174131
    4. Surface association and the MreB cytoskeleton regulate pilus production, localization and function in Pseudomonas aeruginosa. Cowles KN, et al. Mol Microbiol, 2010 Jun. PMID 20398206, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P. aeruginosa injects ExoS into cells through the function of type IV pilus retraction, and that pilT makes a greater contribution to this process than pilU
      Title: The pilT gene contributes to type III ExoS effector injection into epithelial cells in Pseudomonas aeruginosa.
    2. Inactivation of MreB leads to mislocalization of the pilus retraction ATPase PilT, mislocalization of the pili themselves and a reduction in motility.
      Title: Surface association and the MreB cytoskeleton regulate pilus production, localization and function in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pilus retraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within type IV pilus-dependent motility TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in type IV pilus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twitching motility protein PilT
    NP_249086.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      436570..437604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249086.1 twitching motility protein PilT [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249086.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P24559
      Conserved Domains (1) summary
      COG2805
      Location:1 → 342
      PilT; Tfp pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24559.1

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