Nudc nuclear distribution C, dynein complex regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nudcprovided by RGD
Full Name: nuclear distribution C, dynein complex regulatorprovided by RGD
Primary source: RGD:3215
See related: EnsemblRapid:ENSRNOG00000051720 AllianceGenome:RGD:3215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: c15; Silg92
Summary: Predicted to enable unfolded protein binding activity. Involved in nuclear migration and response to peptide hormone. Predicted to be located in cytosol; midbody; and mitotic spindle. Predicted to be active in cytoplasm. Orthologous to human NUDC (nuclear distribution C, dynein complex regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 325.7), Heart (RPKM 265.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151041878..151055260, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (145758006..145771390, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (151754723..151768104, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NudC, like Lis1, is required for neuronal migration during neocorticogenesis.
Title: NudC is required for interkinetic nuclear migration and neuronal migration during neocortical development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131321 (e-PCR)
- UniSTS:214604

RH125442 (e-PCR)
- UniSTS:162262

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear migration protein nudC

Names: clone 15; nuclear distribution C homolog; nuclear distribution gene C homolog; nuclear distribution protein C homolog; nuclear migration protein nudC-like; nudC nuclear distribution protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017271.3 → NP_058967.1 nuclear migration protein nudC

See identical proteins and their annotated locations for NP_058967.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63525

UniProtKB/TrEMBL

A0A8I6A9J2, A6ISX3

Related

ENSRNOP00000073414.1, ENSRNOT00000079380.3

Conserved Domains (4) summary

cd06492
Location:173 → 259

p23_mNUDC_like; p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) ...

PRK06991
Location:66 → 103

PRK06991; electron transport complex subunit RsxB

pfam14050
Location:9 → 60

Nudc_N; N-terminal conserved domain of Nudc

pfam16273
Location:98 → 145

NuDC; Nuclear distribution C domain