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    KLF17 KLF transcription factor 17 [ Homo sapiens (human) ]

    Gene ID: 128209, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KLF17provided by HGNC
    Official Full Name
    KLF transcription factor 17provided by HGNC
    Primary source
    HGNC:HGNC:18830
    See related
    Ensembl:ENSG00000171872 MIM:609602; AllianceGenome:HGNC:18830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZLF393; ZNF393; Zfp393
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within gamete generation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis (RPKM 3.2), endometrium (RPKM 0.4) and 5 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KLF17 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44043927..44135140)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43915021..44006090)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44584493..44600812)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:44471356-44471562 Neighboring gene solute carrier family 6 member 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44476286-44476951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44494509-44495068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44495069-44495626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 804 Neighboring gene uncharacterized LOC107984948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44496268-44496864 Neighboring gene uncharacterized LOC124904168 Neighboring gene VISTA enhancer hs1857 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:44507734-44507907 Neighboring gene uncharacterized LOC124904169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 806 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:44555105-44555823 Neighboring gene KLF17-I enhancer Neighboring gene keratin 8 pseudogene 47 Neighboring gene KLF17 promoter region Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:44585039-44585806 Neighboring gene small nuclear ribonucleoprotein Sm D1 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 479, pseudogene Neighboring gene zinc finger protein 146 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 936 Neighboring gene KLF transcription factor 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells. Li S, et al. J Int Med Res, 2021 Nov. PMID 34738482, Free PMC Article
    2. Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma. Liu FY, et al. Med Oncol, 2013 Mar. PMID 23325444
    3. Reduced Krüppel-like factor 17 (KLF17) expression correlates with poor survival in patients with gastric cancer. Peng JJ, et al. Arch Med Res, 2014 Jul. PMID 24947617
    4. Suppressed Krüppel‑like factor 17 expression induces tumor proliferation, metastasis and a poor prognosis in papillary thyroid carcinoma. Ye WC, et al. Mol Med Rep, 2014 Oct. PMID 25109837
    5. Reduced expression of Krüppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma. Cai XD, et al. Biochem Biophys Res Commun, 2012 Feb 3. PMID 22240024

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
      Title: KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
    2. KLF17 promotes human naive pluripotency but is not required for its establishment.
      Title: KLF17 promotes human naïve pluripotency but is not required for its establishment.
    3. Up-regulation of KLF17 expression increases the sensitivity of gastric cancer to 5-fluorouracil.
      Title: Up-regulation of KLF17 expression increases the sensitivity of gastric cancer to 5-fluorouracil.
    4. Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.
      Title: Effect of KLF17 overexpression on epithelial-mesenchymal transition of gastric cancer cells.
    5. Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17.
      Title: Precision hyperthermia-induced miRNA-409-3p upregulation inhibits migration, invasion, and EMT of gastric cancer cells by targeting KLF17.
    6. Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study.
      Title: Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study.
    7. Kruppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
      Title: Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy.
    8. The above data show that normal levels of melatonin may help in preventing breast cancer metastasis through inhibiting DJ-1/KLF17/ID-1 signaling pathway. The combination of melatonin and taxol is a potent candidate against breast cancer metastasis, better than using melatonin or taxol as a single drug
      Title: Melatonin inhibits breast cancer cell invasion through modulating DJ-1/KLF17/ID-1 signaling pathway.
    9. Results revealed that KLF17 expression was abnormally decreased in colorectal cancer (CRC) and associated with lymph node metastasis and unfavorable overall survival. Moreover, ectopic KLF17 expression suppressed CRC cell growth and invasion in vitro and in vivo. In addition, the downregulation of KLF17 was associated with the hypermethylation of the CpG nucleotides on the KLF17 promoter.
      Title: Clinical significance and biological role of KLF17 as a tumour suppressor in colorectal cancer.
    10. Low Expressions of KLF17 is associated with lung adenocarcinoma.
      Title: Krüppel-like factor 17 inhibits urokinase plasminogen activator gene expression to suppress cell invasion through the Src/p38/ MAPK signaling pathway in human lung adenocarcionma.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ40160

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Krueppel-like factor 17
    Names
    Kruppel like factor 17
    novel zinc-finger protein
    zinc finger protein 393

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173484.4 → NP_775755.3  Krueppel-like factor 17

      See identical proteins and their annotated locations for NP_775755.3

      Status: VALIDATED

      Source sequence(s)
      AL356653, BC049844, DB046781
      Consensus CDS
      CCDS508.1
      UniProtKB/Swiss-Prot
      Q5JT82, Q86VQ7, Q8N805
      Related
      ENSP00000361373.3, ENST00000372299.4
      Conserved Domains (4) summary
      COG5048
      Location:282 → 350
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:285 → 307
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:343 → 365
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:329 → 352
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      44043927..44135140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540700.2 → XP_011539002.1  Krueppel-like factor 17 isoform X1

      See identical proteins and their annotated locations for XP_011539002.1

      Conserved Domains (4) summary
      COG5048
      Location:245 → 313
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:248 → 270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:306 → 328
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:292 → 315
      zf-H2C2_2; Zinc-finger double domain

    2. XM_047445936.1 → XP_047301892.1  Krueppel-like factor 17 isoform X1

    3. XM_047445938.1 → XP_047301894.1  Krueppel-like factor 17 isoform X1

    4. XM_005270465.4 → XP_005270522.2  Krueppel-like factor 17 isoform X2

      Conserved Domains (4) summary
      COG5048
      Location:108 → 211
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:233 → 255
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:219 → 242
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011540704.3 → XP_011539006.1  Krueppel-like factor 17 isoform X3

      Conserved Domains (4) summary
      COG5048
      Location:145 → 232
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:156 → 178
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:214 → 236
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 223
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      43915021..44006090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334414.1 → XP_054190389.1  Krueppel-like factor 17 isoform X1

    2. XM_054334415.1 → XP_054190390.1  Krueppel-like factor 17 isoform X1

    3. XM_054334413.1 → XP_054190388.1  Krueppel-like factor 17 isoform X1

    4. XM_054334416.1 → XP_054190391.1  Krueppel-like factor 17 isoform X2

    5. XM_054334417.1 → XP_054190392.1  Krueppel-like factor 17 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JT82.1 GenPept UniProtKB/Swiss-Prot:Q5JT82

    Gene LinkOut

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