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    mcr alpha-methylacyl-CoA racemase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885067, updated on 6-Oct-2023

    Summary

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    Gene symbol
    mcr
    Gene description
    alpha-methylacyl-CoA racemase
    Locus tag
    Rv1143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (1270062..1271144)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene enoyl-CoA hydratase EchA11 Neighboring gene enoyl-CoA hydratase EchA10 Neighboring gene oxidoreductase Neighboring gene transmembrane transport protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface. Bhaumik P, et al. J Mol Biol, 2007 Apr 6. PMID 17320106
    2. Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold. Savolainen K, et al. J Biol Chem, 2005 Apr 1. PMID 15632186
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCR has unique structural features, not seen in the structures of the sequence related formyl-CoA transferases
      Title: Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.
    2. The active site geometry agrees with a 1,1-proton transfer mechanism in which the acid/base-pair residues are His126 and Asp156.
      Title: The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    alpha-methylacyl-CoA racemase
    NP_215659.1
    • Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1270062..1271144
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_215659.1 alpha-methylacyl-CoA racemase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_215659.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4LWI7
      Conserved Domains (1) summary
      COG1804
      Location:1 → 358
      CaiB; Crotonobetainyl-CoA:carnitine CoA-transferase CaiB and related acyl-CoA transferases [Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    2YIM_A.1
    2YIM_B.1
    2YIM_C.1
    2YIM_D.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials