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    ahpC alkyl hydroperoxide reductase subunit AhpC [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885717, updated on 6-Jun-2024

    Summary

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    Gene symbol
    ahpC
    Gene description
    alkyl hydroperoxide reductase subunit AhpC
    Locus tag
    Rv2428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2726193..2726780)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene gamma-glutamyl phosphate reductase Neighboring gene pseudo Neighboring gene alkyl hydroperoxide reductase AphD Neighboring gene PPE family protein PPE41 Neighboring gene PE family protein PE25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Residues of helix ɑ2 are critical for catalytic efficiency of mycobacterial alkylhydroperoxide reductase subunit C. Chong SMS, et al. FEBS Lett, 2020 Sep. PMID 32557576
    2. Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress. Guimarães BG, et al. J Biol Chem, 2005 Jul 8. PMID 15886207
    3. A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide. Franceschelli JJ, et al. Tuberculosis (Edinb), 2018 Sep. PMID 30205971
    4. Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis. Baker L, et al. Emerg Infect Dis, 2004 Sep. PMID 15498158, Free PMC Article
    5. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Residues of helix a2 are critical for catalytic efficiency of mycobacterial alkylhydroperoxide reductase subunit C.
      Title: Residues of helix ɑ2 are critical for catalytic efficiency of mycobacterial alkylhydroperoxide reductase subunit C.
    2. A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide.
      Title: A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide.
    3. The overall structure folds into a ring-shaped hexamer of dimers instead of the usual pentamer of dimers observed in other reduced peroxiredoxins
      Title: Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress.
    4. A neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient variation to construct a robust phylogenetic tree for M. tuberculosis.
      Title: Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    alkyl hydroperoxide reductase subunit AhpC
    NP_216944.1
    • alkyl hydroperoxidase C

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2726193..2726780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216944.1 alkyl hydroperoxide reductase subunit AhpC [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216944.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0K0YAZ0, A0A654ZMT7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WQB7.1

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