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    pup ubiquitin-like protein Pup [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888788, updated on 6-Oct-2023

    Summary

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    Gene symbol
    pup
    Gene description
    ubiquitin-like protein Pup
    Locus tag
    Rv2111c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2370598..2370792, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene PPE family protein PPE36 Neighboring gene proteasome subunit alpha Neighboring gene proteasome subunit beta Neighboring gene pup deamidase/depupylase Neighboring gene integral membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins. Barandun J, et al. BMC Struct Biol, 2017 Feb 1. PMID 28143508, Free PMC Article
    2. Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway. Imkamp F, et al. EMBO Rep, 2010 Oct. PMID 20798673, Free PMC Article
    3. Prokaryotic ubiquitin-like protein (Pup) is coupled to substrates via the side chain of its C-terminal glutamate. Sutter M, et al. J Am Chem Soc, 2010 Apr 28. PMID 20355727
    4. Prokaryotic ubiquitin-like protein pup is intrinsically disordered. Chen X, et al. J Mol Biol, 2009 Sep 11. PMID 19607839, Free PMC Article
    5. Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein. Liao S, et al. Biochem J, 2009 Aug 13. PMID 19580545

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. When linked to the proteasomal substrates FabD and PanB, Pup is unstructured and retains the ability to interact with its different binding partners.
      Title: Prokaryotic ubiquitin-like protein remains intrinsically disordered when covalently attached to proteasomal target proteins.
    2. Transient binding of Mpa to the proteasome core particle controls the fate of Pup.
      Title: Fate of pup inside the Mycobacterium proteasome studied by in-cell NMR.
    3. Dop deamidates Pup by cleaving the isopeptide bond of Pup-tagged substrates.
      Title: Dop functions as a depupylase in the prokaryotic ubiquitin-like modification pathway.
    4. Prokaryotic ubiquitin-like protein (Pup) is coupled to substrate proteins via an isopeptide bond in order to target them for degradation by the proteasome.
      Title: Prokaryotic ubiquitin-like protein (Pup) is coupled to substrates via the side chain of its C-terminal glutamate.
    5. N-terminal coiled-coil domain of Mpa makes extensive contacts along the central region of Pup leaving its N-terminus unconstrained and available for other functional interactions.
      Title: A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa.
    6. ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes
      Title: Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes.
    7. These findings provide mechanistic insights into Pup's functional role as a protein degradation signal.
      Title: Prokaryotic ubiquitin-like protein pup is intrinsically disordered.
    8. Prokaryotic ubiquitin-like protein (Pup) is a member of an intrinsically disordered protein superfamily.
      Title: Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein.
    9. study identified a prokaryotic ubiquitin-like protein, Pup (Rv2111c), which was specifically conjugated to proteasome substrates in Mycobacterium tuberculosis; pupylation occurred on lysines and required proteasome accessory factor A (PafA)
      Title: Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    ubiquitin-like protein Pup

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2370598..2370792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216627.1 ubiquitin-like protein Pup [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216627.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3LBL7
      Conserved Domains (1) summary
      pfam05639
      Location:3 → 64
      Pup; Pup-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WHN5.1

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