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    vapC21 ribonuclease VapC21 [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888249, updated on 6-Oct-2023

    Summary

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    Gene symbol
    vapC21
    Gene description
    ribonuclease VapC21
    Locus tag
    Rv2757c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (3070170..3070586, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene thymidylate synthase ThyX Neighboring gene type I restriction/modification system DNA methylase HsdM Neighboring gene antitoxin VapB21 Neighboring gene ribonuclease VapC42 Neighboring gene antitoxin VapB42 Neighboring gene type I restriction/modification system specificity determinant HsdS Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of VapC21 from Mycobacterium tuberculosis at 1.31 Å resolution. Jardim P, et al. Biochem Biophys Res Commun, 2016 Sep 23. PMID 27576202
    2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VapC21 is a dimer in solution, with conserved active site architecture and an extensive antitoxin binding groove.
      Title: Crystal structure of VapC21 from Mycobacterium tuberculosis at 1.31 Å resolution.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    ribonuclease VapC21
    NP_217273.1
    • toxin, part of toxin-antitoxin (TA) operon with Rv2758c,contains PIN domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3070170..3070586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217273.1 ribonuclease VapC21 [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217273.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2I7WB33, R4M8U6
      Conserved Domains (1) summary
      cd18755
      Location:6 → 133
      PIN_MtVapC3_VapC21-like; VapC-like PIN domain of Mycobacterium tuberculosis VapC3, VapC21 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WF91.1

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