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    cyp125 steroid C26-monooxygenase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887782, updated on 17-Dec-2024

    Summary

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    Gene symbol
    cyp125
    Gene description
    steroid C26-monooxygenase
    Locus tag
    Rv3545c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (3984144..3985445, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene lipid transfer protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene acyl-CoA dehydrogenase FadE29 Neighboring gene acyl-CoA dehydrogenase FadE28 Neighboring gene acetyl-CoA acetyltransferase FadA Neighboring gene deazaflavin-dependent nitroreductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis. Carroll P, et al. PLoS One, 2015. PMID 26197389, Free PMC Article
    2. Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Ouellet H, et al. Mol Microbiol, 2010 Aug. PMID 20545858, Free PMC Article
    3. The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. McLean KJ, et al. J Biol Chem, 2009 Dec 18. PMID 19846552, Free PMC Article
    4. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. Capyk JK, et al. J Biol Chem, 2009 Dec 18. PMID 19846551, Free PMC Article
    5. Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. Conner KP, et al. Biochemistry, 2015 Feb 10. PMID 25591012, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. M. tuberculosis cytochrome P450 Cyp125 plays a key role in cholesterol metabolism being involved in the first steps of its degradation
      Title: Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.
    2. Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1.
      Title: Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1.
    3. CYP125A1 plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one.
      Title: Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one.
    4. The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
      Title: The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
    5. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
      Title: Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
    6. Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable.
      Title: Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    steroid C26-monooxygenase
    NP_218062.1
    • cytochrome P450 Cyp125

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      3984144..3985445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218062.1 steroid C26-monooxygenase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218062.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAX1S955
      Conserved Domains (1) summary
      cd11033
      Location:43 → 425
      CYP142-like; cytochrome P450 family 142 and similar cytochrome P450s
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3IVY_A.1
    3IW0_A.1
    3IW1_A.1
    3IW2_A.1
    P9WPP1.1

    Gene LinkOut

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    Molecular Biology Databases