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    Zbtb2 zinc finger and BTB domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 381990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb2provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 2provided by MGI
    Primary source
    MGI:MGI:2685949
    See related
    Ensembl:ENSMUSG00000075327 AllianceGenome:MGI:2685949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1103
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Orthologous to human ZBTB2 (zinc finger and BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 12.1), ovary adult (RPKM 5.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb2 in Genome Data Viewer
    Location:
    10 A1; 10 2.06 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4317074..4353114, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4367074..4388108, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:6084769-6084970 Neighboring gene STARR-seq mESC enhancer starr_25646 Neighboring gene STARR-seq mESC enhancer starr_25645 Neighboring gene STARR-seq mESC enhancer starr_25640 Neighboring gene A kinase anchor protein 12 Neighboring gene predicted gene, 40592 Neighboring gene STARR-seq mESC enhancer starr_25637 Neighboring gene STARR-positive B cell enhancer ABC_E11428 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5999414-5999597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5988889-5989072 Neighboring gene STARR-seq mESC enhancer starr_25630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5958087-5958270 Neighboring gene STARR-positive B cell enhancer ABC_E2315 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_25628 Neighboring gene coiled-coil domain containing 170 Neighboring gene predicted gene, 22739

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB2 reads unmethylated CpG island promoters and regulates embryonic stem cell differentiation. Karemaker ID, et al. EMBO Rep, 2018 Apr. PMID 29437775, Free PMC Article
    2. ZBTB2, a novel master regulator of the p53 pathway. Jeon BN, et al. J Biol Chem, 2009 Jul 3. PMID 19380588, Free PMC Article
    3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    4. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
    5. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033466.3 → NP_001028638.2  zinc finger and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_001028638.2

      Status: VALIDATED

      Source sequence(s)
      AK132308, AK173184, BY444820
      Consensus CDS
      CCDS56674.1
      UniProtKB/TrEMBL
      Q3V1Q5, Q3V3W4
      Related
      ENSMUSP00000097656.3, ENSMUST00000100078.10
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 84
      BTB; BTB/POZ domain
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001359811.1 → NP_001346740.1  zinc finger and BTB domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      AC133902, AK030936, AK160748, BC094553, BY443983
      Consensus CDS
      CCDS56674.1
      UniProtKB/TrEMBL
      Q3V1Q5, Q3V3W4
      Related
      ENSMUSP00000097655.4, ENSMUST00000100077.5
      Conserved Domains (4) summary
      sd00017
      Location:365 → 385
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363 → 385
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 84
      BTB; BTB/POZ domain
      pfam13465
      Location:377 → 399
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      4317074..4353114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155875.1 → XP_036011768.1  zinc finger and BTB domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q505G7
      Conserved Domains (4) summary
      sd00017
      Location:286 → 306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:1 → 38
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00096
      Location:284 → 306
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:298 → 320
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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