TXNL4B thioredoxin like 4B [Homo sapiens (human)] - Gene

Summary

Official Symbol: TXNL4Bprovided by HGNC
Official Full Name: thioredoxin like 4Bprovided by HGNC
Primary source: HGNC:HGNC:26041
See related: Ensembl:ENSG00000140830 MIM:617722; AllianceGenome:HGNC:26041
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DLP; Dim2
Summary: Predicted to be involved in mRNA splicing, via spliceosome. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary (RPKM 7.1), testis (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q22.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (72084857..72094378, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (77901171..77912511, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (72118756..72128277, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A crystal structure of TXNL4B was determined at 1.33 A resolution and refined to an Rwork of 0.13 and an Rfree of 0.18 with one native dimer in the asymmetric unit.
Title: High-resolution crystal structure of human Dim2/TXNL4B.
The human gene coding for the spliceosomal protein thioredoxin-like 4B (TXNL4B) was overexpressed in Escherichia coli and the encoded protein was purified and crystallized.
Title: Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein TXNL4B.
DLP is implicated in not only cell cycle progression but also in a more specific molecular process such as pre-mRNA splicing
Title: DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression.
crystal structure; in contrast to hDim1, hDim2 forms stable homodimers
Title: Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of thioredoxin-like 4B (TXNL4B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

L18426 (e-PCR)
- UniSTS:34648

D16S2593E (e-PCR)
- UniSTS:151663

D16S2606E (e-PCR)
- UniSTS:151674

D16S3235 (e-PCR)
- UniSTS:49809

RH64997 (e-PCR)
- UniSTS:85193

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thioredoxin-like protein 4B

Names: Dim1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142317.2 → NP_001135789.1 thioredoxin-like protein 4B isoform 1

See identical proteins and their annotated locations for NP_001135789.1

Status: VALIDATED

Source sequence(s)

AC009087, BC009646, DA499499

Consensus CDS

CCDS10906.1

UniProtKB/Swiss-Prot

D3DWS6, Q9NX01

UniProtKB/TrEMBL

Q53GP2

Related

ENSP00000408130.1, ENST00000423037.5

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...
NM_001142318.2 → NP_001135790.1 thioredoxin-like protein 4B isoform 1

See identical proteins and their annotated locations for NP_001135790.1

Status: VALIDATED

Source sequence(s)

AC009087, BC009646, CD517462

Consensus CDS

CCDS10906.1

UniProtKB/Swiss-Prot

D3DWS6, Q9NX01

UniProtKB/TrEMBL

Q53GP2

Related

ENSP00000392310.2, ENST00000426362.6

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...
NM_001324354.2 → NP_001311283.1 thioredoxin-like protein 4B isoform 2

Status: VALIDATED

Source sequence(s)

AC009087

UniProtKB/TrEMBL

H3BUL8

Related

ENSP00000457699.1, ENST00000569767.1

Conserved Domains (1) summary

cl00388
Location:10 → 95

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
NM_001324355.2 → NP_001311284.1 thioredoxin-like protein 4B isoform 3

Status: VALIDATED

Source sequence(s)

AC009087, BM849401
NM_017853.3 → NP_060323.1 thioredoxin-like protein 4B isoform 1

See identical proteins and their annotated locations for NP_060323.1

Status: VALIDATED

Source sequence(s)

AC009087, BC009646, BP355646

Consensus CDS

CCDS10906.1

UniProtKB/Swiss-Prot

D3DWS6, Q9NX01

UniProtKB/TrEMBL

Q53GP2

Related

ENSP00000268483.3, ENST00000268483.8

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...