Hmbox1 homeobox containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hmbox1provided by MGI
Official Full Name: homeobox containing 1provided by MGI
Primary source: MGI:MGI:2445066
See related: Ensembl:ENSMUSG00000021972 AllianceGenome:MGI:2445066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: F830020C16Rik
Summary: Enables telomeric DNA binding activity. Involved in telomere maintenance via telomerase. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; limb mesenchyme; and urinary system. Orthologous to human HMBOX1 (homeobox containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in lung adult (RPKM 16.3), thymus adult (RPKM 10.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.79 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (65049049..65187354, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (64811600..64949899, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7 cells proliferation based on UPLC-MS/MS.
Title: Metabolomic analysis reveals the influence of HMBOX1 on RAW264.7 cells proliferation based on UPLC-MS/MS.
N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury.
Title: N6-methyladenosine modification on Hmbox1 is related to telomere dysfunction in DEHP-induced male reproductive injury.
HMBOX1 participated in the functional maintenance of mouse aortic endothelial cells, the aortic endothelial cells of HMBOX1 KO mouse showed increased apoptosis and decreased autophagy with lipopolysaccharidetreatment.
Title: Loss of HMBOX1 promotes LPS-induced apoptosis and inhibits LPS-induced autophagy of vascular endothelial cells in mouse.
HMBOX1 in hepatocytes acts as a key immunosuppressive factor for inflammation
Title: HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation.
Hmbox1 is a key regulator in the differentiation of embryonic stem cells into vascular endothelial cells.
Title: A chemical small molecule induces mouse embryonic stem cell differentiation into functional vascular endothelial cells via Hmbox1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI451877 (e-PCR)
- UniSTS:160404

RH144424 (e-PCR)
- UniSTS:233669

AI604847 (e-PCR)
- UniSTS:180680

RH118355 (e-PCR)
- UniSTS:160984

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded telomeric DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: homeobox-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347626.2 → NP_001334555.1 homeobox-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AC132602, AC141425

Consensus CDS

CCDS84150.1

UniProtKB/TrEMBL

H3BKF8, H3BKM3

Related

ENSMUSP00000135448.2, ENSMUST00000176128.8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
NM_001347627.2 → NP_001334556.1 homeobox-containing protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC132602, AC141425

Consensus CDS

CCDS84149.1

UniProtKB/TrEMBL

H3BK13

Related

ENSMUSP00000022544.8, ENSMUST00000022544.14

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
NM_177338.7 → NP_796312.2 homeobox-containing protein 1 isoform 2

See identical proteins and their annotated locations for NP_796312.2

Status: VALIDATED

Source sequence(s)

AC132602, AC141425

Consensus CDS

CCDS36955.1

UniProtKB/Swiss-Prot

Q80WC2, Q8BJA3, Q8BWE7, Q99LV1

UniProtKB/TrEMBL

H3BKF8

Related

ENSMUSP00000066905.4, ENSMUST00000067843.10

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

65049049..65187354 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247768.2 → XP_030103628.1 homeobox-containing protein 1 isoform X9

UniProtKB/TrEMBL

H3BK13

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_030247767.2 → XP_030103627.1 homeobox-containing protein 1 isoform X9

UniProtKB/TrEMBL

H3BK13

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245031.4 → XP_011243333.1 homeobox-containing protein 1 isoform X4

UniProtKB/TrEMBL

H3BKF8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245029.4 → XP_011243331.1 homeobox-containing protein 1 isoform X3

UniProtKB/TrEMBL

H3BKF8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245036.4 → XP_011243338.1 homeobox-containing protein 1 isoform X8

See identical proteins and their annotated locations for XP_011243338.1

UniProtKB/TrEMBL

H3BK13

Related

ENSMUSP00000135211.2, ENSMUST00000176832.8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245035.4 → XP_011243337.1 homeobox-containing protein 1 isoform X8

See identical proteins and their annotated locations for XP_011243337.1

UniProtKB/TrEMBL

H3BK13

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_030247765.2 → XP_030103625.1 homeobox-containing protein 1 isoform X2

UniProtKB/TrEMBL

H3BKF8

Related

ENSMUSP00000135372.3, ENSMUST00000177326.8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_030247766.2 → XP_030103626.1 homeobox-containing protein 1 isoform X6

UniProtKB/TrEMBL

H3BJ31, H3BK67

Related

ENSMUSP00000135272.2, ENSMUST00000175744.8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245037.4 → XP_011243339.1 homeobox-containing protein 1 isoform X10

UniProtKB/TrEMBL

H3BK13

Related

ENSMUSP00000135657.3, ENSMUST00000175905.8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245034.4 → XP_011243336.1 homeobox-containing protein 1 isoform X7

See identical proteins and their annotated locations for XP_011243336.1

UniProtKB/TrEMBL

H3BK13

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_006518882.5 → XP_006518945.1 homeobox-containing protein 1 isoform X1

UniProtKB/TrEMBL

H3BKF8

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_011245033.4 → XP_011243335.1 homeobox-containing protein 1 isoform X5

See identical proteins and their annotated locations for XP_011243335.1

UniProtKB/TrEMBL

H3BJ31

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus
XM_036158568.1 → XP_036014461.1 homeobox-containing protein 1 isoform X8

UniProtKB/TrEMBL

H3BK13

Conserved Domains (2) summary

cd00086
Location:268 → 340

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

pfam04814
Location:25 → 227

HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N-terminus