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    NCKAP5L NCK associated protein 5 like [ Homo sapiens (human) ]

    Gene ID: 57701, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NCKAP5Lprovided by HGNC
    Official Full Name
    NCK associated protein 5 likeprovided by HGNC
    Primary source
    HGNC:HGNC:29321
    See related
    Ensembl:ENSG00000167566 MIM:615104; AllianceGenome:HGNC:29321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cep169; FP1193; KIAA1602
    Summary
    Involved in microtubule bundle formation and microtubule depolymerization. Located in centrosome and microtubule plus-end. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 5.5), testis (RPKM 5.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCKAP5L in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49791152..49828413, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49754152..49791427, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (50184935..50222196, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:50134965-50135656 Neighboring gene transmembrane BAX inhibitor motif containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6332 Neighboring gene MPRA-validated peak1728 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6334 Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50184530-50185372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:50195140-50195640 Neighboring gene nuclear-encoded mitochondrial tRNA-Gln (TTG) 6-1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:50218728-50219594 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:50219595-50220461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:50222070-50222648 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:50222649-50223227 Neighboring gene BCDIN3D antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6337 Neighboring gene BCDIN3 domain containing RNA methyltransferase Neighboring gene ribosomal protein L35a pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Cep169-interacting proteins and the in vivo modification sites of Cep169 via proteomic analysis. Shintomi M, et al. Biochem Biophys Res Commun, 2018 Jan 15. PMID 29269292
    2. Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis. Mori Y, et al. Biochem Biophys Res Commun, 2015 Dec 25. PMID 26549230
    3. Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability. Mori Y, et al. PLoS One, 2015. PMID 26485573, Free PMC Article
    4. mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells. Merle DA, et al. Antioxidants (Basel), 2021 Dec 3. PMID 34943047, Free PMC Article
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings suggest that Cep169 regulates cell growth by interacting with multiple proteins.
      Title: Identification of Cep169-interacting proteins and the in vivo modification sites of Cep169 via proteomic analysis.
    2. These results show that Cep169 targets microtubule tips and regulates stability of microtubules with CDK5RAP2.
      Title: Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability.
    3. These data suggest that the dissociation of Cep169 from centrosomes is controlled by Cdk1/Cyclin B during mitosis, and that Cep169 might regulate MT dynamics of mitotic spindle.
      Title: Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36581, KIAA1602, MGC129863

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nck-associated protein 5-like
    Names
    NCKAP5-like
    centrosomal protein of 169 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037806.4 → NP_001032895.2  nck-associated protein 5-like

      See identical proteins and their annotated locations for NP_001032895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC131157, BC033253, BU617503, BX327000, CN359941, CN359946
      Consensus CDS
      CCDS41781.2
      UniProtKB/Swiss-Prot
      Q2TB26, Q71RH1, Q8N4W1, Q96HX2, Q9HCH0
      Related
      ENSP00000337998.6, ENST00000335999.7
      Conserved Domains (1) summary
      pfam15246
      Location:879 → 1183
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    2. NM_001368048.1 → NP_001354977.1  nck-associated protein 5-like

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC131157
      Consensus CDS
      CCDS41781.2
      UniProtKB/Swiss-Prot
      Q2TB26, Q71RH1, Q8N4W1, Q96HX2, Q9HCH0

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      49791152..49828413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719525.3 → XP_006719588.1  nck-associated protein 5-like isoform X1

      See identical proteins and their annotated locations for XP_006719588.1

      UniProtKB/Swiss-Prot
      Q2TB26, Q71RH1, Q8N4W1, Q96HX2, Q9HCH0
      Conserved Domains (1) summary
      pfam15246
      Location:879 → 1183
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    2. XM_005269050.4 → XP_005269107.1  nck-associated protein 5-like isoform X2

      Conserved Domains (1) summary
      pfam15246
      Location:879 → 1183
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    3. XM_047429230.1 → XP_047285186.1  nck-associated protein 5-like isoform X2

    4. XM_011538611.3 → XP_011536913.1  nck-associated protein 5-like isoform X1

      See identical proteins and their annotated locations for XP_011536913.1

      UniProtKB/Swiss-Prot
      Q2TB26, Q71RH1, Q8N4W1, Q96HX2, Q9HCH0
      Conserved Domains (1) summary
      pfam15246
      Location:879 → 1183
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      49754152..49791427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372712.1 → XP_054228687.1  nck-associated protein 5-like isoform X2

    2. XM_054372710.1 → XP_054228685.1  nck-associated protein 5-like isoform X1

      UniProtKB/Swiss-Prot
      Q2TB26, Q71RH1, Q8N4W1, Q96HX2, Q9HCH0

    3. XM_054372713.1 → XP_054228688.1  nck-associated protein 5-like isoform X2

    4. XM_054372711.1 → XP_054228686.1  nck-associated protein 5-like isoform X1

      UniProtKB/Swiss-Prot
      Q2TB26, Q71RH1, Q8N4W1, Q96HX2, Q9HCH0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCH0.4 GenPept UniProtKB/Swiss-Prot:Q9HCH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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