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    ACP5 acid phosphatase 5, tartrate resistant [ Homo sapiens (human) ]

    Gene ID: 54, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ACP5provided by HGNC
    Official Full Name
    acid phosphatase 5, tartrate resistantprovided by HGNC
    Primary source
    HGNC:HGNC:124
    See related
    Ensembl:ENSG00000102575 MIM:171640; AllianceGenome:HGNC:124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPAP; TRAP; TRAcP; TRACP5a; TRACP5b; TrATPase
    Summary
    This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008]
    Expression
    Broad expression in lung (RPKM 55.0), kidney (RPKM 29.2) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ACP5 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11574660..11578975, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11702190..11706505, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11685475..11689790, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14022 Neighboring gene calponin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11662408-11663379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14024 Neighboring gene Sharpr-MPRA regulatory region 7075 Neighboring gene elongation factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14025 Neighboring gene uncharacterized LOC124904638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11687946-11688558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11688559-11689170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14027 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11692934-11693099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14029 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene 76 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11708237-11709235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10124 Neighboring gene zinc finger protein 627 Neighboring gene MPRA-validated peak3358 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tartrate-resistant acid phosphatase activity and glutathione levels are modulated during hFOB 1.19 osteoblastic differentiation. de Souza Malaspina TS, et al. J Mol Histol, 2008 Dec. PMID 18979172
    2. Human tartrate-resistant acid phosphatase becomes an effective ATPase upon proteolytic activation. Mitić N, et al. Arch Biochem Biophys, 2005 Jul 15. PMID 15950921
    3. Localisation of high acid phosphotyrosine phosphatase activity in afferent arterioles and glomeruli of human kidney. Partanen S. J Mol Histol, 2005 May. PMID 16200454
    4. Effects of proteolysis and reduction on phosphatase and ROS-generating activity of human tartrate-resistant acid phosphatase. Fagerlund KM, et al. Arch Biochem Biophys, 2006 May 15. PMID 16620768
    5. Increased tartrate-resistant acid phosphatase (TRAP) expression in malignant breast, ovarian and melanoma tissue: an investigational study. Honig A, et al. BMC Cancer, 2006 Jul 25. PMID 16869970, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction.
      Title: Inhibition of tartrate-resistant acid phosphatase 5 can prevent cardiac fibrosis after myocardial infarction.
    2. Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.
      Title: Spondyloenchondrodysplasia with immune dysregulation related to ACP5. A report of 4 cases.
    3. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
      Title: Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial.
    4. Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.
      Title: Spondyloenchondrodysplasia in five new patients: identification of three novel ACP5 variants with variable neurological presentations.
    5. The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.
      Title: The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.
    6. Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating beta-catenin signaling.
      Title: Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling.
    7. microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity.
      Title: microRNA-877 contributes to decreased non-small cell lung cancer cell growth via the PI3K/AKT pathway by targeting tartrate resistant acid phosphatase 5 activity.
    8. Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.
      Title: Expression of tartrate-resistant acid phosphatase and cathepsin K during osteoclast differentiation in developing mouse mandibles.
    9. Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.
      Title: Intensive weight gain therapy in patients with anorexia nervosa results in improved serum tartrate-resistant acid phosphatase (TRAP) 5a and 5b isoform protein levels.
    10. MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites.
      Title: MMP-8, TRAP-5, and OPG Levels in GCF Diagnostic Potential to Discriminate between Healthy Patients', Mild and Severe Periodontitis Sites.
    Submit: New GeneRIF Correction See all GeneRIFs (76)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Spondyloenchondrodysplasia with immune dysregulation
    MedGen: C1842763 OMIM: 607944 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of acid phosphatase 5, tartrate resistant (ACP5) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117378

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bone resorption IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of macrophage cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tartrate-resistant acid phosphatase type 5
    Names
    human purple acid phosphatase
    tartrate-resistant acid ATPase
    tartrate-resistant acid phosphatase 5a
    tartrate-resistant acid phosphatase 5b
    NP_001104504.1
    NP_001104505.1
    NP_001104506.1
    NP_001308952.1
    NP_001602.1
    XP_005259995.1
    XP_011526371.1
    XP_047294900.1
    XP_047294901.1
    XP_054177203.1
    XP_054177204.1
    XP_054177205.1
    XP_054177206.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028127.1 RefSeqGene

      Range
      6342..9327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1218

    mRNA and Protein(s)

    1. NM_001111034.3 → NP_001104504.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001104504.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      BC025414, BP367008
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Related
      ENSP00000512173.1, ENST00000695791.1
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    2. NM_001111035.3 → NP_001104505.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001104505.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      BC025414, BC111014, BP334409
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Related
      ENSP00000218758.4, ENST00000218758.10
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    3. NM_001111036.3 → NP_001104506.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001104506.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      BC025414, BX365007
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Related
      ENSP00000392374.1, ENST00000412435.7
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    4. NM_001322023.2 → NP_001308952.1  tartrate-resistant acid phosphatase type 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC020947, BC025414, BP334409
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    5. NM_001611.5 → NP_001602.1  tartrate-resistant acid phosphatase type 5 precursor

      See identical proteins and their annotated locations for NP_001602.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein.
      Source sequence(s)
      AK290717, BC025414
      Consensus CDS
      CCDS12265.1
      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Related
      ENSP00000496973.1, ENST00000648477.1
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      11574660..11578975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438944.1 → XP_047294900.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      Related
      ENSP00000512191.1, ENST00000695811.1

    2. XM_011528069.3 → XP_011526371.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_011526371.1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Related
      ENSP00000497140.2, ENST00000649386.2
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    3. XM_005259938.2 → XP_005259995.1  tartrate-resistant acid phosphatase type 5 isoform X1

      See identical proteins and their annotated locations for XP_005259995.1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
      UniProtKB/TrEMBL
      A0A8Q3SI79
      Related
      ENSP00000468767.3, ENST00000592828.7
      Conserved Domains (1) summary
      cd07378
      Location:26 → 311
      MPP_ACP5; Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain

    4. XM_047438945.1 → XP_047294901.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11702190..11706505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321229.1 → XP_054177204.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

    2. XM_054321230.1 → XP_054177205.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

    3. XM_054321228.1 → XP_054177203.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7

    4. XM_054321231.1 → XP_054177206.1  tartrate-resistant acid phosphatase type 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V2, P13686, Q2TAB1, Q6IAS6, Q9UCJ5, Q9UCJ6, Q9UCJ7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13686.3 GenPept UniProtKB/Swiss-Prot:P13686

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