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    DDX31 DEAD-box helicase 31 [ Homo sapiens (human) ]

    Gene ID: 64794, updated on 10-Dec-2024

    Summary

    Official Symbol
    DDX31provided by HGNC
    Official Full Name
    DEAD-box helicase 31provided by HGNC
    Primary source
    HGNC:HGNC:16715
    See related
    Ensembl:ENSG00000125485 MIM:616533; AllianceGenome:HGNC:16715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPP1R25
    Summary
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DDX31 in Genome Data Viewer
    Location:
    9q34.13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (132592997..132669983, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (144804196..144881203, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135468384..135545370, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 77 Neighboring gene uncharacterized LOC124902293 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:135406706-135406978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135462359-135463211 Neighboring gene NANOG hESC enhancer GRCh37_chr9:135467821-135468322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135486212-135486944 Neighboring gene BarH like homeobox 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135545227-135546094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29221 Neighboring gene general transcription factor IIIC subunit 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135597764-135598270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135599285-135599790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135608498-135608998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135608999-135609499 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:135620695-135621194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29222 Neighboring gene Sharpr-MPRA regulatory region 7884 Neighboring gene adenylate kinase 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:135683689-135684190 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:135711155-135711317 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13633, FLJ14578, FLJ23349

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent DNA helicase DDX31
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
    DEAD box protein 31
    DEAD/DEXH helicase DDX31
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
    G2 helicase
    helicain
    probable ATP-dependent RNA helicase DDX31
    protein phosphatase 1, regulatory subunit 25
    NP_001309269.2
    NP_001309270.1
    NP_001309271.1
    NP_001309272.1
    NP_001309273.2
    NP_073616.7
    NP_619526.2
    XP_011517223.2
    XP_011517224.2
    XP_047279689.1
    XP_047279690.1
    XP_047279691.1
    XP_047279692.1
    XP_047279693.1
    XP_047279694.1
    XP_047279695.1
    XP_054219531.1
    XP_054219532.1
    XP_054219533.1
    XP_054219534.1
    XP_054219535.1
    XP_054219536.1
    XP_054219537.1
    XP_054219538.1
    XP_054219539.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322340.2NP_001309269.2  ATP-dependent DNA helicase DDX31 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL160165, AL354735
      UniProtKB/TrEMBL
      B4DYZ1
      Conserved Domains (2) summary
      PRK01297
      Location:21507
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cd17949
      Location:136339
      DEADc_DDX31; DEAD-box helicase domain of DEAD box protein 31
    2. NM_001322341.2NP_001309270.1  ATP-dependent DNA helicase DDX31 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL160165, AL354735
      UniProtKB/TrEMBL
      B4DYZ1
      Conserved Domains (4) summary
      PRK01297
      Location:37570
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cd00268
      Location:136348
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:405527
      Helicase_C; Helicase conserved C-terminal domain
      pfam13959
      Location:597658
      DUF4217; Domain of unknown function (DUF4217)
    3. NM_001322342.1NP_001309271.1  ATP-dependent DNA helicase DDX31 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL160165, AL354735
      UniProtKB/TrEMBL
      B4DYZ1
      Conserved Domains (4) summary
      smart00487
      Location:77274
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:55267
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:324446
      Helicase_C; Helicase conserved C-terminal domain
      pfam13959
      Location:516577
      DUF4217; Domain of unknown function (DUF4217)
    4. NM_001322343.1NP_001309272.1  ATP-dependent DNA helicase DDX31 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL160165, AL354735
      UniProtKB/TrEMBL
      B4DYZ1
      Conserved Domains (4) summary
      PRK01297
      Location:1537
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cd00268
      Location:103315
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:372494
      Helicase_C; Helicase conserved C-terminal domain
      pfam13959
      Location:564625
      DUF4217; Domain of unknown function (DUF4217)
    5. NM_001322344.2NP_001309273.2  ATP-dependent DNA helicase DDX31 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL160165
      Consensus CDS
      CCDS83433.2
      Related
      ENSP00000479697.2, ENST00000480876.3
      Conserved Domains (2) summary
      PRK01297
      Location:28189
      PRK01297; ATP-dependent RNA helicase RhlB; Provisional
      cl28899
      Location:136196
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    6. NM_022779.9NP_073616.7  ATP-dependent DNA helicase DDX31 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL160165, AL354735
      Consensus CDS
      CCDS6951.2
      UniProtKB/TrEMBL
      B4DYZ1
      Related
      ENSP00000361232.4, ENST00000372159.8
      Conserved Domains (3) summary
      COG0513
      Location:123617
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd17949
      Location:136339
      DEADc_DDX31; DEAD-box helicase domain of DEAD box protein 31
      pfam13959
      Location:589649
      DUF4217; Domain of unknown function (DUF4217)
    7. NM_138620.2NP_619526.2  ATP-dependent DNA helicase DDX31 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a shorter and alternate 3' region, as compared to variant 1. Since the first 3 nt of the alternate region is just an in-frame translation stop codon, this variant encodes a C-terminal truncated isoform (2) compared to isoform 1.
      Source sequence(s)
      AL160165
      Consensus CDS
      CCDS6952.2
      UniProtKB/TrEMBL
      A0AAK2PNZ4
      Related
      ENSP00000310539.2, ENST00000310532.7
      Conserved Domains (2) summary
      cd17949
      Location:136339
      DEADc_DDX31; DEAD-box helicase domain of DEAD box protein 31
      cl38915
      Location:376480
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases

    RNA

    1. NR_136309.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL160165, AL354735

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      132592997..132669983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423735.1XP_047279691.1  ATP-dependent DNA helicase DDX31 isoform X5

      UniProtKB/TrEMBL
      B4DYZ1
    2. XM_047423739.1XP_047279695.1  ATP-dependent DNA helicase DDX31 isoform X9

    3. XM_011518922.4XP_011517224.2  ATP-dependent DNA helicase DDX31 isoform X4

    4. XM_047423734.1XP_047279690.1  ATP-dependent DNA helicase DDX31 isoform X3

      UniProtKB/TrEMBL
      B4DYZ1
    5. XM_011518921.4XP_011517223.2  ATP-dependent DNA helicase DDX31 isoform X1

      UniProtKB/TrEMBL
      B4DYZ1
    6. XM_047423733.1XP_047279689.1  ATP-dependent DNA helicase DDX31 isoform X2

    7. XM_047423738.1XP_047279694.1  ATP-dependent DNA helicase DDX31 isoform X8

    8. XM_047423736.1XP_047279692.1  ATP-dependent DNA helicase DDX31 isoform X6

    9. XM_047423737.1XP_047279693.1  ATP-dependent DNA helicase DDX31 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      144804196..144881203 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363560.1XP_054219535.1  ATP-dependent DNA helicase DDX31 isoform X5

      UniProtKB/TrEMBL
      B4DYZ1
    2. XM_054363564.1XP_054219539.1  ATP-dependent DNA helicase DDX31 isoform X9

    3. XM_054363559.1XP_054219534.1  ATP-dependent DNA helicase DDX31 isoform X4

    4. XM_054363558.1XP_054219533.1  ATP-dependent DNA helicase DDX31 isoform X3

      UniProtKB/TrEMBL
      B4DYZ1
    5. XM_054363556.1XP_054219531.1  ATP-dependent DNA helicase DDX31 isoform X1

      UniProtKB/TrEMBL
      B4DYZ1
    6. XM_054363557.1XP_054219532.1  ATP-dependent DNA helicase DDX31 isoform X2

    7. XM_054363563.1XP_054219538.1  ATP-dependent DNA helicase DDX31 isoform X8

    8. XM_054363561.1XP_054219536.1  ATP-dependent DNA helicase DDX31 isoform X6

    9. XM_054363562.1XP_054219537.1  ATP-dependent DNA helicase DDX31 isoform X7