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    FOXRED1 FAD dependent oxidoreductase domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 55572, updated on 10-Dec-2024

    Summary

    Official Symbol
    FOXRED1provided by HGNC
    Official Full Name
    FAD dependent oxidoreductase domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:26927
    See related
    Ensembl:ENSG00000110074 MIM:613622; AllianceGenome:HGNC:26927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H17; FP634; MC1DN19
    Summary
    This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in brain (RPKM 6.2), liver (RPKM 5.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FOXRED1 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (126269154..126278126)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (126298638..126309536)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126139049..126148021)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 118 member B Neighboring gene RNA, U4 small nuclear 86, pseudogene Neighboring gene MPRA-validated peak1502 silencer Neighboring gene MPRA-validated peak1503 silencer Neighboring gene SRP receptor subunit alpha Neighboring gene RNA, 7SL, cytoplasmic 351, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5705 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:126147427-126147591 Neighboring gene uncharacterized LOC124902838 Neighboring gene ribosomal protein L35a pseudogene 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    FAD-dependent oxidoreductase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028029.1 RefSeqGene

      Range
      5115..14087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001425160.1 → NP_001412089.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5
      Related
      ENSP00000508540.1, ENST00000692336.1
    2. NM_001425161.1 → NP_001412090.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5
    3. NM_001425163.1 → NP_001412092.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5
    4. NM_001425164.1 → NP_001412093.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5, A0A8J9AK24
      Related
      ENSP00000434178.2, ENST00000532125.2
    5. NM_001425165.1 → NP_001412094.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5
    6. NM_001425166.1 → NP_001412095.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5
    7. NM_001425167.1 → NP_001412096.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KTW5
    8. NM_001425168.1 → NP_001412097.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
    9. NM_001425169.1 → NP_001412098.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
    10. NM_001425170.1 → NP_001412099.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
      Related
      ENST00000534011.6
    11. NM_001425171.1 → NP_001412100.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      B4DI59, B4DQI0
    12. NM_001425172.1 → NP_001412101.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      B4DI59, B4DQI0
    13. NM_001425173.1 → NP_001412102.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KSK3
    14. NM_001425174.1 → NP_001412103.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KSK3
    15. NM_001425175.1 → NP_001412104.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AP001318
      UniProtKB/TrEMBL
      A0A8I5KSK3
    16. NM_017547.4 → NP_060017.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_060017.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AL136923, DA056004
      Consensus CDS
      CCDS8471.1
      UniProtKB/Swiss-Prot
      B3KN84, B4DHU2, Q71MG0, Q96CU9, Q9BU39, Q9UKY9
      UniProtKB/TrEMBL
      A0A8I5KTW5
      Related
      ENSP00000263578.5, ENST00000263578.10
      Conserved Domains (1) summary
      COG0665
      Location:77 → 478
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    RNA

    1. NR_037647.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK302039, AL136923, AP001318, DA056004
      Related
      ENST00000525770.5
    2. NR_037648.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK295267, AL136923, AP001318
      Related
      ENST00000687699.1
    3. NR_189143.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP001318
      Related
      ENST00000685765.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      126269154..126278126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427252.1 → XP_047283208.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KTW5
    2. XM_017018002.2 → XP_016873491.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
      Conserved Domains (1) summary
      COG0665
      Location:9 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
    3. XM_047427253.1 → XP_047283209.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KSK3
    4. XM_006718879.4 → XP_006718942.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006718942.1

      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
      Conserved Domains (1) summary
      COG0665
      Location:9 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      126298638..126309536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369340.1 → XP_054225315.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
    2. XM_054369339.1 → XP_054225314.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KTW5
    3. XM_054369341.1 → XP_054225316.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4
    4. XM_054369342.1 → XP_054225317.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5KSK3
    5. XM_054369343.1 → XP_054225318.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DI59, B4DXM1, E7EWJ4