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    HSP90AA2P heat shock protein 90 alpha family class A member 2, pseudogene [ Homo sapiens (human) ]

    Gene ID: 3324, updated on 27-Dec-2024

    Summary

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    Official Symbol
    HSP90AA2Pprovided by HGNC
    Official Full Name
    heat shock protein 90 alpha family class A member 2, pseudogeneprovided by HGNC
    Primary source
    HGNC:HGNC:5256
    See related
    MIM:140575; AllianceGenome:HGNC:5256
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPCA; HSPCAL3; HSP90AA2; HSP90ALPHA
    Summary
    HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008]
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    Genomic context

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    See HSP90AA2P in Genome Data Viewer
    Location:
    11p14.1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (27888171..27891092, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (28028805..28031726, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27909718..27912639, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:27743527-27744035 Neighboring gene uncharacterized LOC124902652 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27762065-27762756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27817576-27818442 Neighboring gene CBX3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4547 Neighboring gene uncharacterized LOC124902653 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:27955621-27956820 Neighboring gene uncharacterized LOC124902654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition. Wang S, et al. Biochim Biophys Acta Mol Cell Res, 2024 Mar. PMID 38280407
    2. Cytoplasmic HSP90α expression is associated with perineural invasion in pancreatic cancer. Jiang H, et al. Int J Clin Exp Pathol, 2014. PMID 25031753, Free PMC Article
    3. Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Zou M, et al. Oncogene, 2017 Apr. PMID 27721406, Free PMC Article
    4. Identification of heat shock protein 90α as an IMH-2 epitope-associated protein and correlation of its mRNA overexpression with colorectal cancer metastasis and poor prognosis. Chen WS, et al. Int J Colorectal Dis, 2011 Aug. PMID 21519806
    5. Interaction of the middle domains stabilizes Hsp90α dimer in a closed conformation with high affinity for p23. Synoradzki K, et al. Biol Chem, 2018 Mar 28. PMID 29337688

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition.
      Title: HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition.
    2. Extracellular Hsp90alpha stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.
      Title: Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress.
    3. Heat-shock protein 90alpha is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.
      Title: Heat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.
    4. Value of HSP90alpha in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.
      Title: Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.
    5. Heat shock protein 90alpha in nipple discharge as a potential tumor marker for breast cancer.
      Title: Heat shock protein 90α in nipple discharge as a potential tumor marker for breast cancer.
    6. Extracellular Hsp90alpha Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
      Title: Extracellular Hsp90α Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.
    7. Modulation of Human Hsp90alpha Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain.
      Title: Modulation of Human Hsp90α Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain.
    8. High HSP90 alpha expression is associated with Endothelial-mesenchymal transition leading to exacerbate pancreatic ductal adenocarcinoma.
      Title: Endothelial-mesenchymal transition harnesses HSP90α-secreting M2-macrophages to exacerbate pancreatic ductal adenocarcinoma.
    9. there was no difference in Hsp90alpha levels between overweight and obese children and healthy controls. Hsp90 isoforms had different expression in NAFLD patients. Also, Hsp90alpha levels were lower in overweight and obese NAFLD patients. However, Hsp90alpha to Hsp90beta ratio had better accuracy for NAFLD diagnosis in obese and overweight patients compared to individual biomarkers.
      Title: Circulating Hsp90 Isoform Levels in Overweight and Obese Children and the Relation to Nonalcoholic Fatty Liver Disease: Results from a Cross-Sectional Study.
    10. Study suggests that HSP90AA2 gene polymorphisms are associated with SLE susceptibility in Chinese population.
      Title: Associations of HSP90AA2 gene polymorphisms with disease susceptibility, glucocorticoids efficacy and health-related quality of life in Chinese systemic lupus erythematosus patients.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • heat shock 90kD protein, alpha-like 3
    • heat shock 90kDa protein 1, alpha-like 3
    • heat shock protein 86
    • heat shock protein 90kDa alpha (cytosolic), class A member 1 pseudogene
    • heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
    • heat shock protein 90kDa alpha family class A member 2, pseudogene

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005856.3 

      Range
      101..3022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      27888171..27891092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      28028805..28031726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040141.1: Suppressed sequence

      Description
      NM_001040141.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14568.2 GenPept UniProtKB/Swiss-Prot:Q14568

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.