Cd207 CD207 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd207provided by MGI
Official Full Name: CD207 antigenprovided by MGI
Primary source: MGI:MGI:2180021
See related: Ensembl:ENSMUSG00000034783 AllianceGenome:MGI:2180021
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables carbohydrate binding activity. Predicted to be involved in defense response to virus and immune response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in epidermis; lymph node; spleen; and thymus. Orthologous to human CD207 (CD207 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 1.7), mammary gland adult (RPKM 0.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83648189..83654839, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83671207..83677857, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Study the involvement of Langerin in mediating epicutaneous sensitization of atopic dermatitis-like mouse model].
Title: [Study the involvement of Langerin in mediating epicutaneous sensitization of atopic dermatitis-like mouse model].
Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model.
Title: Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model.
We identified that wall teichoic acid, an abundant polymer on the S. aureus surface, is recognized by langerin, a receptor unique to Langerhans cells.
Title: Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses.
Data show that the development of langerhans cells (LC) from embryonic and bone marrow-derived progenitors and langerin(+ )conventional dendritic cells (DC) is regulated by the retinoic acid receptor alpha (RARalpha)-retinoic acid (RA) axis.
Title: RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells.
Binding analysis between purified long and short forms of langerin and a series of keratin sulfate disaccharide components shows that the binding critically requires the 6-sulfation of Gal and that the long form of langerin displays higher affinity than the short form.
Title: High affinity sugar ligands of C-type lectin receptor langerin.
Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent
Title: Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent.
Data show that Candida albicans and Candida tropicalis preferentially localized in (and persisted within) a sub- population of Peyer's patch Langerin-positive dendritic cells.
Title: Sampling of Candida albicans and Candida tropicalis by Langerin-positive dendritic cells in mouse Peyer's patches.
Langerin is expressed by the XCR1(+) "DC1" population of mice.
Title: Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells.
Langerin+ dermal dendritic cells appear to be site- and strain-specific
Title: Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice.
TLR7-activated langerin(neg) dendritic cells trigger psoriatic plaque formation via IL-23-mediated activation of innate IL-17/IL-22-producing lymphocytes, independently of IFN-I.
Title: Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: C-type lectin domain family 4 member K

Names: Langerhans cell specific c-type lectin; langerin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144943.3 → NP_659192.2 C-type lectin domain family 4 member K

See identical proteins and their annotated locations for NP_659192.2

Status: VALIDATED

Source sequence(s)

AC090647, AK142731

Consensus CDS

CCDS39534.1

UniProtKB/Swiss-Prot

Q8R442, Q8VBX4

UniProtKB/TrEMBL

Q8VDD4

Related

ENSMUSP00000040746.7, ENSMUST00000037882.8

Conserved Domains (1) summary

cd03590
Location:201 → 324

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83648189..83654839 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506139.2 → XP_006506202.1 C-type lectin domain family 4 member K isoform X1

UniProtKB/TrEMBL

Q8VDD4

Conserved Domains (2) summary

cd03590
Location:201 → 323

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

COG1196
Location:97 → 196

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]