CD300E CD300e molecule [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD300Eprovided by HGNC
Official Full Name: CD300e moleculeprovided by HGNC
Primary source: HGNC:HGNC:28874
See related: Ensembl:ENSG00000186407 MIM:609801; AllianceGenome:HGNC:28874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CLM2; CLM-2; IREM2; PIgR2; IREM-2; PIgR-2; CD300LE; CMRF35-A5
Summary: This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]
Expression: Biased expression in appendix (RPKM 19.2), bone marrow (RPKM 15.3) and 4 other tissues See more
Orthologs: all
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Genomic context

Location:: 17q25.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (74609885..74623738, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (75500469..75514322, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (72606024..72619877, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation.
Title: The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation.
CD300E expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.
CD300 molecules are all expressed by DC; CD300b, d, e and f are restricted to different subpopulations of the myeloid DC lineage. They have been shown to regulate DC function both in vitro and in vivo.
Title: CD300 molecule regulation of human dendritic cell functions.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
IREM-2 is a novel activating immunoglobulin-like receptor expressed on mature hemopoietic cells of the monocytic and myeloid dendritic cell lineages.
Title: Molecular characterization of a novel immune receptor restricted to the monocytic lineage.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484201

RH123291 (e-PCR)
- UniSTS:135668

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: CMRF35-like molecule 2

Names: CD300 antigen-like family member E; CD300e antigen; immune receptor expressed on myeloid cells 2; poly-Ig receptor 2; polymeric immunoglobulin receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181449.3 → NP_852114.2 CMRF35-like molecule 2 precursor

See identical proteins and their annotated locations for NP_852114.2

Status: VALIDATED

Source sequence(s)

AC064805, AK303545, BC100890

Consensus CDS

CCDS11702.1

UniProtKB/Swiss-Prot

B4DNS1, Q496F6, Q7Z7I3

UniProtKB/TrEMBL

B4E0V9

Related

ENSP00000376395.2, ENST00000392619.2

Conserved Domains (2) summary

cd05716
Location:24 → 104

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:21 → 104

IG_like; Immunoglobulin like