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    Ramp2 receptor (calcitonin) activity modifying protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 54409, updated on 28-Jan-2025

    Summary

    Official Symbol
    Ramp2provided by MGI
    Official Full Name
    receptor (calcitonin) activity modifying protein 2provided by MGI
    Primary source
    MGI:MGI:1859650
    See related
    Ensembl:ENSMUSG00000001240 AllianceGenome:MGI:1859650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables coreceptor activity. Involved in several processes, including cell-cell junction assembly; circulatory system development; and negative regulation of endothelial cell apoptotic process. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be part of adrenomedullin receptor complex. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including central nervous system; forelimb bud; gut; heart; and prostate gland lobe. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RAMP2 (receptor activity modifying protein 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in lung adult (RPKM 313.3), subcutaneous fat pad adult (RPKM 94.5) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Ramp2 in Genome Data Viewer
    Location:
    11 D; 11 64.47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101137160..101139076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101246334..101248250)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein-like 1 Neighboring gene C-C motif chemokine receptor 10 Neighboring gene enhancer of zeste 1 polycomb repressive complex 2 subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101110062-101110171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101114923-101115106 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101115117-101115300 Neighboring gene vacuolar protein sorting 25 Neighboring gene WNK lysine deficient protein kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adrenomedullin binding  
    enables adrenomedullin binding  
    enables adrenomedullin receptor activity  
    enables adrenomedullin receptor activity  
    enables coreceptor activity  
    enables coreceptor activity PubMed 
    enables coreceptor activity  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adherens junction assembly PubMed 
    involved_in adherens junction assembly  
    involved_in adrenomedullin receptor signaling pathway  
    involved_in adrenomedullin receptor signaling pathway  
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in basement membrane assembly PubMed 
    involved_in bicellular tight junction assembly PubMed 
    involved_in bicellular tight junction assembly  
    involved_in calcium ion transport  
    involved_in calcium ion transport  
    involved_in calcium ion transport  
    involved_in cellular response to hormone stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus PubMed 
    involved_in heart development PubMed 
    involved_in intracellular protein transport  
    involved_in negative regulation of endothelial cell apoptotic process PubMed 
    involved_in negative regulation of endothelial cell apoptotic process  
    involved_in negative regulation of vascular permeability PubMed 
    involved_in negative regulation of vascular permeability  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of vasculogenesis PubMed 
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein transport  
    involved_in protein transport  
    involved_in protein transport  
    involved_in receptor internalization  
    involved_in receptor internalization  
    involved_in receptor internalization  
    involved_in regulation of G protein-coupled receptor signaling pathway  
    involved_in regulation of blood pressure PubMed 
    involved_in sprouting angiogenesis PubMed 
    involved_in vascular associated smooth muscle cell development PubMed 
    involved_in vasculogenesis  
    involved_in vasculogenesis  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    part_of adrenomedullin receptor complex  
    part_of adrenomedullin receptor complex  
    is_active_in cell surface  
    located_in cell surface  
    located_in cell surface  
    located_in cytoplasm  
    located_in cytoplasm  
    colocalizes_with plasma membrane  
    colocalizes_with plasma membrane  
    part_of receptor complex  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    receptor activity-modifying protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019444.2NP_062317.1  receptor activity-modifying protein 2 precursor

      See identical proteins and their annotated locations for NP_062317.1

      Status: VALIDATED

      Source sequence(s)
      AK003810, BC051201, BY312723
      Consensus CDS
      CCDS25457.1
      UniProtKB/Swiss-Prot
      Q6IS25, Q9WUP0
      Related
      ENSMUSP00000122072.2, ENSMUST00000129680.8
      Conserved Domains (1) summary
      pfam04901
      Location:83186
      RAMP; Receptor activity modifying family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101137160..101139076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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