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    Anxa6 annexin A6 [ Mus musculus (house mouse) ]

    Gene ID: 11749, updated on 9-Dec-2024

    Summary

    Official Symbol
    Anxa6provided by MGI
    Official Full Name
    annexin A6provided by MGI
    Primary source
    MGI:MGI:88255
    See related
    Ensembl:ENSMUSG00000018340 AllianceGenome:MGI:88255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Anx6; Cabm; Camb; AnxVI
    Summary
    Predicted to enable several functions, including GTP binding activity; cholesterol binding activity; and phospholipid binding activity. Involved in apoptotic signaling pathway and mitochondrial calcium ion homeostasis. Acts upstream of or within calcium ion transport and regulation of muscle contraction. Located in perinuclear region of cytoplasm. Is expressed in lung; meninges; primary palate; vascular system; and yolk sac blood vessel. Orthologous to human ANXA6 (annexin A6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 129.0), limb E14.5 (RPKM 86.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Anxa6 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54869779..54924297, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54978953..55033471, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 3 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11481 Neighboring gene STARR-positive B cell enhancer ABC_E1824 Neighboring gene 40S ribosomal protein S11-like Neighboring gene STARR-seq mESC enhancer starr_29522 Neighboring gene STARR-seq mESC enhancer starr_29523 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54836566-54836859 Neighboring gene predicted gene, 19911 Neighboring gene coiled-coil domain containing 69 Neighboring gene STARR-seq mESC enhancer starr_29527 Neighboring gene STARR-positive B cell enhancer ABC_E161 Neighboring gene STARR-positive B cell enhancer ABC_E8406 Neighboring gene GM2 ganglioside activator protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholesterol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligand-gated monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monoatomic ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of sequestering of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    annexin A6
    Names
    67 kDa calelectrin
    CPB-II
    annexin VI, p68
    annexin-6
    calphobindin-II
    chromobindin-20
    lipocortin VI
    p68
    p70

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110211.2NP_001103681.1  annexin A6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK146509, AK147066, AK160754, BB033332, BY316619
      Consensus CDS
      CCDS48799.1
      UniProtKB/TrEMBL
      F8WIT2, Q3TUI1
      Related
      ENSMUSP00000099788.3, ENSMUST00000102727.3
      Conserved Domains (2) summary
      smart00335
      Location:538587
      ANX; Annexin repeats
      pfam00191
      Location:439504
      Annexin; Annexin
    2. NM_013472.5NP_038500.2  annexin A6 isoform a

      See identical proteins and their annotated locations for NP_038500.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK146509, AK147066, BB033332, BY316619
      Consensus CDS
      CCDS24705.1
      UniProtKB/Swiss-Prot
      P14824, Q8BSS4
      UniProtKB/TrEMBL
      Q3UI56
      Related
      ENSMUSP00000104511.4, ENSMUST00000108883.10
      Conserved Domains (1) summary
      pfam00191
      Location:439504
      Annexin; Annexin

    RNA

    1. NR_138556.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL593846

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54869779..54924297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)