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    Nfe2l1 nuclear factor, erythroid derived 2,-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 18023, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nfe2l1provided by MGI
    Official Full Name
    nuclear factor, erythroid derived 2,-like 1provided by MGI
    Primary source
    MGI:MGI:99421
    See related
    Ensembl:ENSMUSG00000038615 AllianceGenome:MGI:99421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NRF1; Lcrf1; TCF11; LCR-F1; TCF-11
    Summary
    This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases from the use of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 102.3), heart adult (RPKM 69.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nfe2l1 in Genome Data Viewer
    Location:
    11 D; 11 60.12 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96708239..96720810, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96817414..96829968, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1146 Neighboring gene sorting nexin 11 Neighboring gene STARR-seq mESC enhancer starr_30562 Neighboring gene chromobox 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30564 Neighboring gene STARR-seq mESC enhancer starr_30565 Neighboring gene STARR-positive B cell enhancer ABC_E9144 Neighboring gene STARR-positive B cell enhancer ABC_E9371 Neighboring gene STARR-positive B cell enhancer ABC_E201 Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2 Neighboring gene STARR-positive B cell enhancer ABC_E2366 Neighboring gene predicted gene 11523 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (8)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cholesterol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cholesterol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cysteine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fructose 6-phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glial cell fate commitment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glucose 6-phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitotic metaphase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of odontoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of odontoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within regulation of proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    endoplasmic reticulum membrane sensor NFE2L1
    Names
    NF-E2-related factor 1
    NFE2-related factor 1
    locus control region-factor 1
    nuclear factor erythroid 2-related factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130450.1NP_001123922.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

      See identical proteins and their annotated locations for NP_001123922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 5 encode the same isoform.
      Source sequence(s)
      AK038187, BC043063, CN527202
      Consensus CDS
      CCDS25304.1
      UniProtKB/Swiss-Prot
      E9Q038, O70234, Q61985
      UniProtKB/TrEMBL
      Q3U5L0, Q6GTN8
      Related
      ENSMUSP00000128527.2, ENSMUST00000167149.8
      Conserved Domains (1) summary
      cd14720
      Location:620687
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001130451.1NP_001123923.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

      See identical proteins and their annotated locations for NP_001123923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AK038187, CJ144781, CJ152359
      Consensus CDS
      CCDS48893.1
      UniProtKB/TrEMBL
      Q3V3M1
      Related
      ENSMUSP00000131585.2, ENSMUST00000169828.8
      Conserved Domains (1) summary
      cd14720
      Location:332399
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    3. NM_001130452.1NP_001123924.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 2

      See identical proteins and their annotated locations for NP_001123924.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a downstream in-frame ATG, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
      Source sequence(s)
      AK038187, CJ152359
      Consensus CDS
      CCDS48893.1
      UniProtKB/TrEMBL
      Q3V3M1
      Conserved Domains (1) summary
      cd14720
      Location:332399
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    4. NM_001130453.1NP_001123925.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK038187, AK148471, CF163519
      Consensus CDS
      CCDS48894.1
      UniProtKB/TrEMBL
      Q3UFI8, Q3V3M1
      Related
      ENSMUSP00000127804.2, ENSMUST00000167110.8
      Conserved Domains (1) summary
      cd14720
      Location:462529
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    5. NM_001130454.1NP_001123926.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 4

      See identical proteins and their annotated locations for NP_001123926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 5' UTR and 5' coding region which cause translation initiation to occur at a distinct ATG, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK038187, AK148471
      UniProtKB/TrEMBL
      Q3UFI8
      Conserved Domains (1) summary
      cd14720
      Location:451518
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    6. NM_001361682.1NP_001348611.1  endoplasmic reticulum membrane sensor NFE2L1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK038187, AL596384, CF163519, CJ151652
      Conserved Domains (1) summary
      cd14720
      Location:493560
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    7. NM_008686.3NP_032712.2  endoplasmic reticulum membrane sensor NFE2L1 isoform 1

      See identical proteins and their annotated locations for NP_032712.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 5 encode the same isoform.
      Source sequence(s)
      AK038187, AK152040, BC043063, BY301848
      Consensus CDS
      CCDS25304.1
      UniProtKB/Swiss-Prot
      E9Q038, O70234, Q61985
      UniProtKB/TrEMBL
      Q3U5L0, Q6GTN8
      Related
      ENSMUSP00000080467.6, ENSMUST00000081775.12
      Conserved Domains (1) summary
      cd14720
      Location:620687
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96708239..96720810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156406.1XP_036012299.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X4

      Conserved Domains (1) summary
      cd14720
      Location:324391
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    2. XM_036156405.1XP_036012298.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X3

      UniProtKB/TrEMBL
      Q3V3M1
      Conserved Domains (1) summary
      cd14720
      Location:332399
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    3. XM_036156403.1XP_036012296.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X1

      UniProtKB/TrEMBL
      Q3U5L0
      Conserved Domains (1) summary
      cd14720
      Location:567634
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain
    4. XM_036156404.1XP_036012297.1  endoplasmic reticulum membrane sensor NFE2L1 isoform X2

      Conserved Domains (1) summary
      cd14720
      Location:440507
      bZIP_NFE2-like; Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain