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    Tspan17 tetraspanin 17 [ Mus musculus (house mouse) ]

    Gene ID: 74257, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tspan17provided by MGI
    Official Full Name
    tetraspanin 17provided by MGI
    Primary source
    MGI:MGI:1921507
    See related
    Ensembl:ENSMUSG00000025875 AllianceGenome:MGI:1921507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbxo23; Tm4sf17; 2210021G21Rik
    Summary
    Enables enzyme binding activity. Involved in protein maturation. Predicted to be active in plasma membrane. Is expressed in brain; ganglia; neural retina; and ventral grey horn. Orthologous to human TSPAN17 (tetraspanin 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.8), cerebellum adult (RPKM 14.7) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tspan17 in Genome Data Viewer
    Location:
    13 B1; 13 29.41 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54936915..54944588)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54789102..54796775)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34592 Neighboring gene predicted gene 16249 Neighboring gene STARR-positive B cell enhancer mm9_chr13:54890539-54890840 Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene predicted gene, 40959 Neighboring gene predicted gene, 31188

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tetraspanin-17
    Names
    F-box only protein 23
    tetraspan protein SB134
    transmembrane 4 superfamily member 17
    tspan-17
    NP_083117.2
    XP_006517477.1
    XP_006517478.1
    XP_006517480.1
    XP_017171106.1
    XP_017171107.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028841.3NP_083117.2  tetraspanin-17

      See identical proteins and their annotated locations for NP_083117.2

      Status: VALIDATED

      Source sequence(s)
      AI019499, AK008761, BY734818, CD740983
      Consensus CDS
      CCDS26536.1
      UniProtKB/Swiss-Prot
      Q91VI6, Q9D7W4
      UniProtKB/TrEMBL
      Q3TAQ3
      Related
      ENSMUSP00000026993.8, ENSMUST00000026993.14
      Conserved Domains (2) summary
      cd03159
      Location:115235
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:16263
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54936915..54944588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517414.3XP_006517477.1  tetraspanin-17 isoform X1

      See identical proteins and their annotated locations for XP_006517477.1

      UniProtKB/Swiss-Prot
      Q91VI6, Q9D7W4
      Related
      ENSMUSP00000115287.3, ENSMUST00000131692.9
      Conserved Domains (1) summary
      cd03159
      Location:115235
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    2. XM_006517415.3XP_006517478.1  tetraspanin-17 isoform X2

      UniProtKB/Swiss-Prot
      Q91VI6, Q9D7W4
      Conserved Domains (2) summary
      cd03159
      Location:115210
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18191
      Tetraspannin; Tetraspanin family
    3. XM_017315617.2XP_017171106.1  tetraspanin-17 isoform X3

      UniProtKB/TrEMBL
      F6VW20
      Related
      ENSMUSP00000123607.3, ENSMUST00000130568.9
      Conserved Domains (2) summary
      cd03159
      Location:115194
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:18191
      Tetraspannin; Tetraspanin family
    4. XM_006517417.4XP_006517480.1  tetraspanin-17 isoform X5

      Conserved Domains (2) summary
      cl02781
      Location:115194
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:18191
      Tetraspannin; Tetraspanin family
    5. XM_017315618.2XP_017171107.1  tetraspanin-17 isoform X4

      UniProtKB/TrEMBL
      E9PWC3
      Related
      ENSMUSP00000131671.2, ENSMUST00000163796.8
      Conserved Domains (1) summary
      cd03159
      Location:49169
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    RNA

    1. XR_382461.2 RNA Sequence