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    App amyloid beta precursor protein [ Mus musculus (house mouse) ]

    Gene ID: 11820, updated on 9-Dec-2024

    Summary

    Official Symbol
    Appprovided by MGI
    Official Full Name
    amyloid beta precursor proteinprovided by MGI
    Primary source
    MGI:MGI:88059
    See related
    Ensembl:ENSMUSG00000022892 AllianceGenome:MGI:88059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik
    Summary
    Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; nervous system development; and regulation of protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is active in cell surface; intracellular vesicle; and presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; metanephros; peripheral nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See App in Genome Data Viewer
    Location:
    16 C3.3; 16 46.92 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84751236..84972187, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84952666..85175255, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5555 Neighboring gene junction adhesion molecule 2 Neighboring gene predicted gene, 46557 Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene STARR-seq mESC enhancer starr_41374 Neighboring gene GA repeat binding protein, alpha Neighboring gene STARR-seq mESC enhancer starr_41375 Neighboring gene predicted gene 10791 Neighboring gene predicted gene, 49227 Neighboring gene STARR-seq mESC enhancer starr_41378 Neighboring gene STARR-seq mESC enhancer starr_41380 Neighboring gene predicted gene, 41482 Neighboring gene predicted gene, 41483

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PTB domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables PTB domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RAGE receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparan sulfate proteoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables low-density lipoprotein particle receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptidase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within axo-dendritic transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT acts_upstream_of_or_within axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axo-dendritic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within axon midline choice point recognition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to norepinephrine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cognition IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within collateral sprouting in absence of injury IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cytosolic mRNA polyadenylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dendrite development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within intracellular copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in long-term synaptic potentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in low-density lipoprotein particle mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mating behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in microglia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglia development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in modulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood circulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of blood circulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron projection maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron projection maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_positive_effect phospholipase D-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Toll signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelin production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of endothelin production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein trimerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of regulation of amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of dendritic spine maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of long-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of neurotransmitter uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of spontaneous synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of spontaneous synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to yeast ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within suckling behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of amyloid-beta complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in astrocyte projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in axon IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome to plasma membrane transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone filopodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    part_of high-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of intermediate-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in main axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amyloid-beta precursor protein
    Names
    alzheimer disease amyloid A4 protein homolog
    alzheimer disease amyloid protein
    amyloid beta (A4) precursor protein
    amyloid beta A4 protein
    amyloid precursor protein
    amyloidogenic glycoprotein
    appican
    beta-amyloid precursor protein
    protease nexin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198823.1NP_001185752.1  amyloid-beta precursor protein isoform 1 precursor

      See identical proteins and their annotated locations for NP_001185752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK128971, AK159718, BC070409, BP753972
      Consensus CDS
      CCDS88958.1
      UniProtKB/Swiss-Prot
      P12023, P97487, P97942, Q99K32
      UniProtKB/TrEMBL
      Q53ZT3
      Related
      ENSMUSP00000154061.2, ENSMUST00000227723.2
      Conserved Domains (5) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294341
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:677713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:716766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    2. NM_001198824.1NP_001185753.1  amyloid-beta precursor protein isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, AK133639, BC070409, BP753972
      Consensus CDS
      CCDS88956.1
      UniProtKB/TrEMBL
      A0A2I3BQZ9, Q53ZT3
      Related
      ENSMUSP00000154389.2, ENSMUST00000226232.2
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:656694
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:697747
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    3. NM_001198825.1NP_001185754.1  amyloid-beta precursor protein isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, AK133639, BC070409, BP753972
      Consensus CDS
      CCDS88955.1
      UniProtKB/TrEMBL
      A0A2I3BPT1, Q3TXI9
      Related
      ENSMUSP00000153907.2, ENSMUST00000227021.2
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:638676
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:679729
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:347529
      APP_E2; E2 domain of amyloid precursor protein
    4. NM_001198826.1NP_001185755.1  amyloid-beta precursor protein isoform 6 precursor

      See identical proteins and their annotated locations for NP_001185755.1

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, AK159718, BC070409, BP753972
      Consensus CDS
      CCDS88957.1
      UniProtKB/TrEMBL
      Q3TWF3, Q3TXI9
      Related
      ENSMUSP00000154097.2, ENSMUST00000226801.2
      Conserved Domains (7) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:657695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    5. NM_007471.3NP_031497.2  amyloid-beta precursor protein isoform 2 precursor

      See identical proteins and their annotated locations for NP_031497.2

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK128971, BC070409, BP753972
      Consensus CDS
      CCDS28285.1
      UniProtKB/TrEMBL
      Q53ZT3, Q6GR78
      Related
      ENSMUSP00000005406.11, ENSMUST00000005406.12
      Conserved Domains (6) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam02177
      Location:31131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:600638
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:641691
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      84751236..84972187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522873.4XP_006522936.1  amyloid-beta precursor protein isoform X1

      UniProtKB/TrEMBL
      Q53ZT3
      Conserved Domains (4) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam03494
      Location:584620
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:623673
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:291473
      APP_E2; E2 domain of amyloid precursor protein
    2. XM_006522874.3XP_006522937.1  amyloid-beta precursor protein isoform X2

      UniProtKB/TrEMBL
      A0A2I3BR03
      Related
      ENSMUSP00000154401.2, ENSMUST00000227737.2
      Conserved Domains (3) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294341
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:366548
      APP_E2; E2 domain of amyloid precursor protein
    3. XM_036159749.1XP_036015642.1  amyloid-beta precursor protein isoform X3

      Conserved Domains (2) summary
      smart00006
      Location:24188
      A4_EXTRA; amyloid A4
      pfam12925
      Location:291420
      APP_E2; E2 domain of amyloid precursor protein