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    Fads3 fatty acid desaturase 3 [ Mus musculus (house mouse) ]

    Gene ID: 60527, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fads3provided by MGI
    Official Full Name
    fatty acid desaturase 3provided by MGI
    Primary source
    MGI:MGI:1928740
    See related
    Ensembl:ENSMUSG00000024664 AllianceGenome:MGI:1928740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Acts upstream of or within gene expression and unsaturated fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in nervous system; retina; and thoracic segment skeleton. Orthologous to human FADS3 (fatty acid desaturase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 131.2), genital fat pad adult (RPKM 81.0) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Fads3 in Genome Data Viewer
    Location:
    19 A; 19 6.33 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10018189..10037477)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10040855..10060113)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr19:10074872-10075172 Neighboring gene bestrophin 1 Neighboring gene RAB3A interacting protein (rabin3)-like 1 Neighboring gene predicted gene, 29917 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10138709-10138947 Neighboring gene fatty acid desaturase 2 Neighboring gene STARR-seq mESC enhancer starr_45542 Neighboring gene STARR-seq mESC enhancer starr_45543 Neighboring gene STARR-seq mESC enhancer starr_45544 Neighboring gene vesicle-associated membrane protein 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    fatty acid desaturase 3
    Names
    delta(13) desaturase
    delta(13) fatty acid desaturase
    NP_068690.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021890.3NP_068690.3  fatty acid desaturase 3

      See identical proteins and their annotated locations for NP_068690.3

      Status: VALIDATED

      Source sequence(s)
      AA981959, AK029318, AK080414, BY227181
      Consensus CDS
      CCDS29570.1
      UniProtKB/Swiss-Prot
      Q7TND7, Q8C4Y5, Q8CDZ4, Q9JJE7
      UniProtKB/TrEMBL
      Q3T9H9, Q3U3X6
      Related
      ENSMUSP00000111659.3, ENSMUST00000115995.4
      Conserved Domains (2) summary
      PLN03199
      Location:27444
      PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
      cd03506
      Location:168417
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10018189..10037477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003952799.2 RNA Sequence

    2. XR_003952800.2 RNA Sequence