U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult [ Mus musculus (house mouse) ]

    Gene ID: 17879, updated on 24-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Myh1provided by MGI
    Official Full Name
    myosin, heavy polypeptide 1, skeletal muscle, adultprovided by MGI
    Primary source
    MGI:MGI:1339711
    See related
    Ensembl:ENSMUSG00000056328 AllianceGenome:MGI:1339711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IId; MdMs; IId/x; Myhs-f; Myhsf2; MHC2X/D; Myhs-f2; MHC-2X/D; MYHC-IIX; MyHC-IId/x; MyHC-IIx/d; A530084A17Rik
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction. Located in A band and intercalated disc. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; integumental system; and skeletal musculature. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 25.2), lung adult (RPKM 11.6) and 2 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Myh1 in Genome Data Viewer
    Location:
    11 B3; 11 40.59 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67090922..67115401)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67200102..67224577)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29795 Neighboring gene STARR-seq mESC enhancer starr_29796 Neighboring gene predicted gene, 53683 Neighboring gene myosin, heavy polypeptide 2, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene STARR-seq mESC enhancer starr_29797 Neighboring gene myosin, heavy polypeptide 8, skeletal muscle, perinatal Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss. Jung J, et al. Exp Mol Med, 2024 Nov. PMID 39482536, Free PMC Article
    2. A possible regulatory role for conserved promoter motifs in an adult-specific muscle myosin gene from mouse. Takeda S, et al. J Biol Chem, 1992 Aug 25. PMID 1324916
    3. Slow myosin heavy chain expression in the absence of muscle activity. Agbulut O, et al. Am J Physiol Cell Physiol, 2009 Jan. PMID 18945940
    4. Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts. Watanabe N, et al. Biochem Biophys Res Commun, 2020 Apr 30. PMID 32093891
    5. Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains. Allen DL, et al. Dev Biol, 2001 Jan 15. PMID 11150240

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
      Title: Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.
    2. Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
      Title: Endogenous slow and fast myosin dynamics in myofibers isolated from mice expressing GFP-Myh7 and Kusabira Orange-Myh1.
    3. Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.
      Title: Oleic acid up-regulates myosin heavy chain (MyHC) 1 expression and increases mitochondrial mass and maximum respiration in C2C12 myoblasts.
    4. Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.
      Title: Single Muscle Immobilization Decreases Single-Fibre Myosin Heavy Chain Polymorphism: Possible Involvement of p38 and JNK MAP Kinases.
    5. The maintenance of the relative expression of slow MHC-1 protein is independent of neuromuscular activity in mice.
      Title: Slow myosin heavy chain expression in the absence of muscle activity.
    6. p38alpha/beta MAPKs-mediated coactivator recruitment at a proximal MEF-2 site is important for MyHCIId/x gene regulation in skeletal muscle.
      Title: The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC117705

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of muscle myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myosin filament IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    myosin-1
    Names
    myHC-2x
    myosin heavy chain 1
    myosin heavy chain 2X
    myosin heavy chain, skeletal muscle, adult 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030679.2 → NP_109604.1  myosin-1

      See identical proteins and their annotated locations for NP_109604.1

      Status: VALIDATED

      Source sequence(s)
      AK041122, BC108329
      Consensus CDS
      CCDS24855.1
      UniProtKB/Swiss-Prot
      Q32P18, Q5SX40
      UniProtKB/TrEMBL
      B2RWX0
      Related
      ENSMUSP00000117569.2, ENSMUST00000124516.8
      Conserved Domains (3) summary
      cd14910
      Location:100 → 773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:853 → 1930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67090922..67115401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314318.3 → XP_017169807.1  myosin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q32P18, Q5SX40
      UniProtKB/TrEMBL
      B2RWX0
      Related
      ENSMUSP00000018637.9, ENSMUST00000018637.15
      Conserved Domains (3) summary
      cd14910
      Location:100 → 773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:853 → 1930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:35 → 73
      Myosin_N; Myosin N-terminal SH3-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SX40.1 GenPept UniProtKB/Swiss-Prot:Q5SX40

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools