Rasgef1b RasGEF domain family, member 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasgef1bprovided by MGI
Official Full Name: RasGEF domain family, member 1Bprovided by MGI
Primary source: MGI:MGI:2443755
See related: Ensembl:ENSMUSG00000089809 AllianceGenome:MGI:2443755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpig4; GPIgamma4; 4732452O09Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in early endosome; late endosome; and midbody. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; branchial arch; limb bud; vestibulo-cochlear ganglion; and vibrissa. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 14.1), frontal lobe adult (RPKM 11.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 48.46 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (99365279..99400786, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (99217420..99252927, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Behavioral, neurochemical and neuroimmune features of RasGEF1b deficient mice.
Title: Behavioral, neurochemical and neuroimmune features of RasGEF1b deficient mice.
Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages.
Title: Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages.
Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute Kidney Injury Cell Model.
Title: Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute Kidney Injury Cell Model.
Toll-like Receptor (TLR)-induced Rasgef1b expression in macrophages is regulated by NF-kappaB through its proximal promoter.
Title: Toll-like Receptor (TLR)-induced Rasgef1b expression in macrophages is regulated by NF-κB through its proximal promoter.
The authors show that knockdown of the lipopolysaccharide (LPS)-induced cytoplasmic circular RNA, mcircRasGEF1B, results in altered expression of a wide array of genes. Pathway analysis revealed an overall enrichment of genes involved in cell cycle progression, mitotic division, active metabolism, and of particular interest, NF-kappaB, LPS signaling pathways, and macrophage activation.
Title: Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway.
Upon toll-like receptor activation, RasGEF1b may trigger Ras-like proteins and regulate specific biological activities of macrophages.
Title: Early endosome localization and activity of RasGEF1b, a toll-like receptor-inducible Ras guanine-nucleotide exchange factor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-GEF domain-containing family member 1B

Names: GPI-gamma 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145839.2 → NP_665838.1 ras-GEF domain-containing family member 1B isoform 1

See identical proteins and their annotated locations for NP_665838.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer protein (isoform 1).

Source sequence(s)

AK149812, BC052726, BY130572, BY431575

Consensus CDS

CCDS39179.1

UniProtKB/Swiss-Prot

F5H8M5, Q3UE12, Q8C189, Q8JZL7

UniProtKB/TrEMBL

E9Q813

Related

ENSMUSP00000031276.9, ENSMUST00000031276.15

Conserved Domains (2) summary

cd06224
Location:42 → 167

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

pfam00617
Location:209 → 403

RasGEF; RasGEF domain
NM_181318.4 → NP_851835.1 ras-GEF domain-containing family member 1B isoform 2

See identical proteins and their annotated locations for NP_851835.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AK028756, BY130572, BY431575

Consensus CDS

CCDS51570.1

UniProtKB/TrEMBL

E9Q813

Related

ENSMUSP00000129652.2, ENSMUST00000168092.8

Conserved Domains (2) summary

cd06224
Location:42 → 166

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

pfam00617
Location:208 → 401

RasGEF; RasGEF domain