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    H2bc24 H2B clustered histone 24 [ Mus musculus (house mouse) ]

    Gene ID: 665622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H2bc24provided by MGI
    Official Full Name
    H2B clustered histone 24provided by MGI
    Primary source
    MGI:MGI:3710645
    See related
    Ensembl:ENSMUSG00000069303 AllianceGenome:MGI:3710645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4bc24; Gm11277; Hist1h2br
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in thymus adult (RPKM 99.7), colon adult (RPKM 57.2) and 24 other tissues See more
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    Genomic context

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    See H2bc24 in Genome Data Viewer
    Location:
    13 A3.1; 13 8.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22017913..22021700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21833743..21837530)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 18 Neighboring gene H2A clustered histone 24 Neighboring gene STARR-positive B cell enhancer mm9_chr13:21932431-21932732 Neighboring gene nuclear encoded tRNA leucine 2 (anticodon TAA) Neighboring gene STARR-positive B cell enhancer ABC_E1457 Neighboring gene nuclear encoded tRNA isoleucine 11 (anticodon AAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone cluster 1 H2br
    Names
    H2b histone family member

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110555.1 → NP_001104025.1  histone cluster 1 H2br isoform 1

      See identical proteins and their annotated locations for NP_001104025.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AL589879
      Consensus CDS
      CCDS49215.1
      UniProtKB/TrEMBL
      A0JLV3, Q8CBB6
      Related
      ENSMUSP00000136792.2, ENSMUST00000180288.2
      Conserved Domains (2) summary
      pfam00125
      Location:3 → 102
      Histone; Core histone H2A/H2B/H3/H4
      cl23830
      Location:12 → 125
      H2B; Histone H2B

    2. NM_001313878.1 → NP_001300807.1  histone cluster 1 H2br isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AL589879
      Consensus CDS
      CCDS84011.1
      UniProtKB/Swiss-Prot
      P10853, Q5SZZ3
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00000106093.2, ENSMUST00000110467.2
      Conserved Domains (1) summary
      smart00427
      Location:28 → 124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      22017913..22021700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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