Thoc1 THO complex 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thoc1provided by MGI
Official Full Name: THO complex 1provided by MGI
Primary source: MGI:MGI:1919668
See related: Ensembl:ENSMUSG00000024287 AllianceGenome:MGI:1919668
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: tho1; NMP-84; 3110002N20Rik
Summary: Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in early conceptus and embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 14.3), CNS E18 (RPKM 13.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.91 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (9958176..9995486)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (9958180..9995484)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results found that Thoc1 deficiency delays embryo death, and suggest that Thoc1 is required to support increased expression of E2f and apoptotic regulatory genes that trigger apoptosis upon Rb1 loss.
Title: Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
granulocyte macrophage progenitors have a cell autonomous requirement for Thoc1 to maintain cell growth and viability
Title: The Thoc1 encoded ribonucleoprotein is required for myeloid progenitor cell homeostasis in the adult mouse.
Thoc1 gene deletion prevents prostate cancer progression in mice, but has little effect on normal tissue. Prostate cancer cells deprived of Thoc1 show gene expression defects that compromise cell growth.
Title: The Thoc1 ribonucleoprotein and prostate cancer progression.
Thoc1 loss compromises the proliferation and lineage-generating capacity of small intestinal stem cells, disrupting the supply of differentiated cells in this rapidly renewing tissue.
Title: The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.
This suggests NEDD4-1 functions in conjunction with other post-translational mechanisms to regulate Thoc1 protein and THO activity.
Title: The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase.
results demonstrate that NO-mediated thoc1 downregulation, via Nrf2, is a key step in the cancer cell apoptosis induced by CCL-34-treated macrophages
Title: The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent.
THOC5/Fms interacting protein is an essential element in the maintenance of hematopoiesis, and depletion of THOC5/Fms interacting protein causes the down-regulation of THOC1, which may contribute to altered THO complex function and cell death
Title: THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
These findings support the notion that Thoc1-mediated RNP assembly contributes to the coordinated expression of genes necessary for normal differentiation and development in vivo.
Title: Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.
The generation and phenotypic characterization of mice containing a null allele of the Thoc1 gene is described.
Title: Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126430 (e-PCR)
- UniSTS:163138

AU015773 (e-PCR)
- UniSTS:167241

AW107452 (e-PCR)
- UniSTS:181081

AW107924 (e-PCR)
- UniSTS:181082

Thoc1 (e-PCR), detects polymorphism
- UniSTS:497276

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of THO complex	ISO Inferred from Sequence Orthology more info
part_of THO complex part of transcription export complex	IBA Inferred from Biological aspect of Ancestor more info
part_of THO complex part of transcription export complex	IEA Inferred from Electronic Annotation more info
part_of THO complex part of transcription export complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: THO complex subunit 1

Names: nuclear matrix protein p84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417745.1 → NP_001404674.1 THO complex subunit 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC114677, AC163451
NM_001417749.1 → NP_001404678.1 THO complex subunit 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC114677, AC163451
NM_001417750.1 → NP_001404679.1 THO complex subunit 1 isoform 4

Status: VALIDATED

Source sequence(s)

AC114677, AC163451
NM_001417753.1 → NP_001404682.1 THO complex subunit 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC114677, AC163451
NM_001417754.1 → NP_001404683.1 THO complex subunit 1 isoform 5

Status: VALIDATED

Source sequence(s)

AC114677, AC163451
NM_001417760.1 → NP_001404689.1 THO complex subunit 1 isoform 6

Status: VALIDATED

Source sequence(s)

AC114677, AC163451
NM_153552.4 → NP_705780.1 THO complex subunit 1 isoform 1

See identical proteins and their annotated locations for NP_705780.1

Status: VALIDATED

Source sequence(s)

AC114677, AC163451

Consensus CDS

CCDS37733.1

UniProtKB/Swiss-Prot

Q8BWD5, Q8BXY3, Q8R3N6

Related

ENSMUSP00000025137.8, ENSMUST00000025137.9

Conserved Domains (2) summary

cd08318
Location:565 → 650

Death_NMPP84; Death domain of Nuclear Matrix Protein P84

pfam11957
Location:74 → 539

efThoc1; THO complex subunit 1 transcription elongation factor