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    Mettl21c methyltransferase 21C, AARS1 lysine [ Mus musculus (house mouse) ]

    Gene ID: 433294, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mettl21cprovided by MGI
    Official Full Name
    methyltransferase 21C, AARS1 lysineprovided by MGI
    Primary source
    MGI:MGI:3611450
    See related
    Ensembl:ENSMUSG00000047343 AllianceGenome:MGI:3611450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A530098C11Rik
    Summary
    Enables protein-lysine N-methyltransferase activity. Involved in protein methylation. Acts upstream of or within several processes, including cellular response to dexamethasone stimulus; hormone-mediated apoptotic signaling pathway; and regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in alimentary system; diaphragm; genitourinary system; skeletal muscle; and skin. Orthologous to human METTL21C (methyltransferase 21C, AARS1 lysine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Mettl21c in Genome Data Viewer
    Location:
    1 C1.1; 1 23.52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (44048559..44081745, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (44009399..44042620, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26352 Neighboring gene CapStarr-seq enhancers MGSCv37_chr1:43990329-43990512 and MGSCv37_chr1:43990576-43990763 Neighboring gene STARR-seq mESC enhancer starr_00794 Neighboring gene tripeptidyl peptidase II Neighboring gene STARR-seq mESC enhancer starr_00795 Neighboring gene STARR-seq mESC enhancer starr_00796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:44099123-44099276 Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein-lysine methyltransferase METTL21C
    Names
    methyltransferase like 21C
    methyltransferase-like protein 21C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013799.1NP_001013821.1  protein-lysine methyltransferase METTL21C

      See identical proteins and their annotated locations for NP_001013821.1

      Status: PROVISIONAL

      Source sequence(s)
      AK041301
      Consensus CDS
      CCDS14927.1
      UniProtKB/Swiss-Prot
      Q8BLU2
      UniProtKB/TrEMBL
      B2RVS5
      Related
      ENSMUSP00000061229.4, ENSMUST00000061421.4
      Conserved Domains (1) summary
      cl17173
      Location:56224
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      44048559..44081745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496128.4XP_006496191.1  protein-lysine methyltransferase METTL21C isoform X1

      See identical proteins and their annotated locations for XP_006496191.1

      UniProtKB/Swiss-Prot
      Q8BLU2
      UniProtKB/TrEMBL
      B2RVS5
      Conserved Domains (1) summary
      cl17173
      Location:56224
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_006496126.5XP_006496189.1  protein-lysine methyltransferase METTL21C isoform X1

      See identical proteins and their annotated locations for XP_006496189.1

      UniProtKB/Swiss-Prot
      Q8BLU2
      UniProtKB/TrEMBL
      B2RVS5
      Conserved Domains (1) summary
      cl17173
      Location:56224
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...