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    Grem2 gremlin 2, DAN family BMP antagonist [ Mus musculus (house mouse) ]

    Gene ID: 23893, updated on 9-Dec-2024

    Summary

    Official Symbol
    Grem2provided by MGI
    Official Full Name
    gremlin 2, DAN family BMP antagonistprovided by MGI
    Primary source
    MGI:MGI:1344367
    See related
    Ensembl:ENSMUSG00000050069 AllianceGenome:MGI:1344367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prdc; Gremlin2
    Summary
    Enables BMP binding activity; heparin binding activity; and identical protein binding activity. Involved in several processes, including determination of dorsal identity; embryonic body morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including central nervous system; chondrocranium; gut; integument; and lung. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human GREM2 (gremlin 2, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 15.0), lung adult (RPKM 14.2) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Grem2 in Genome Data Viewer
    Location:
    1 H3; 1 81.08 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (174661352..174749386, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (174833785..174921911, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene formin 2 Neighboring gene STARR-seq mESC enhancer starr_03094 Neighboring gene lines homolog 2 pseudogene Neighboring gene predicted gene, 51689 Neighboring gene STARR-seq mESC enhancer starr_03095 Neighboring gene STARR-seq mESC enhancer starr_03096 Neighboring gene STARR-seq mESC enhancer starr_03097 Neighboring gene STARR-seq mESC enhancer starr_03098 Neighboring gene STARR-seq mESC enhancer starr_03100 Neighboring gene regulator of G protein signaling 7 Neighboring gene predicted gene, 53483 Neighboring gene STARR-seq mESC enhancer starr_03101 Neighboring gene STARR-positive B cell enhancer ABC_E5859 Neighboring gene STARR-seq mESC enhancer starr_03102 Neighboring gene predicted gene, 36307

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables BMP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    gremlin-2
    Names
    Gremlin1
    cysteine knot superfamily 1, BMP antagonist 2
    gremlin 2 homolog, cysteine knot superfamily
    protein related to DAN and cerberus

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001421483.1NP_001408412.1  gremlin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117627
      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
    2. NM_001421484.1NP_001408413.1  gremlin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117627
      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
    3. NM_001421485.1NP_001408414.1  gremlin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117627
      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
    4. NM_001421486.1NP_001408415.1  gremlin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC117627
      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
    5. NM_011825.2NP_035955.1  gremlin-2 precursor

      See identical proteins and their annotated locations for NP_035955.1

      Status: VALIDATED

      Source sequence(s)
      AC117627
      Consensus CDS
      CCDS15545.1
      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
      Related
      ENSMUSP00000049640.4, ENSMUST00000055294.4
      Conserved Domains (1) summary
      pfam03045
      Location:51158
      DAN; DAN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      174661352..174749386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)